Cameron D W, Ngugi E N, Ronald A R, Simonsen J N, Braddick M, Bosire M, Kimata J, Kamala J, Ndinya-Achola J O, Waiyaki P G
Department of Medical Microbiology, University of Nairobi, Kenya.
Sex Transm Dis. 1991 Jul-Sep;18(3):188-91. doi: 10.1097/00007435-199107000-00013.
Control of genital ulcer disease (GUD) is a proposed intervention to slow the dissemination of human immunodeficiency virus (HIV) infection. Programs for the control of sexually transmitted diseases (STD) should focus on groups of high-frequency transmitters, such as prostitutes and their clientele. This study illustrates the interaction between the prevalence of chancroid, use of barrier prophylaxis against STDs, and HIV infection in a population of female prostitutes in Nairobi. Four hundred and twenty three women were evaluated. Despite the increased use of condoms, the prevalence of genital ulcers remained constant between 1986-87 and 1987-88. Genital ulcer disease was simultaneously associated with HIV infection (adjusted odds ratio: 3.7, P less than .01) whereas it was independently and inversely associated with more consistent condom use (P less than .01). The authors conclude that genital ulcer disease can be controlled in these populations but concurrent HIV infection increases the difficulty of this intervention.
控制生殖器溃疡疾病（GUD）是一项旨在减缓人类免疫缺陷病毒（HIV）感染传播的干预措施。性传播疾病（STD）控制项目应关注高频传播人群，如妓女及其顾客。本研究阐述了在内罗毕女性妓女群体中，软下疳患病率、性传播疾病屏障预防措施的使用与HIV感染之间的相互作用。对423名女性进行了评估。尽管避孕套使用有所增加，但1986 - 87年至1987 - 88年期间生殖器溃疡的患病率保持不变。生殖器溃疡疾病与HIV感染同时相关（调整后的优势比：3.7，P <.01），而与更持续地使用避孕套独立且呈负相关（P <.01）。作者得出结论，在这些人群中生殖器溃疡疾病可以得到控制，但同时存在的HIV感染增加了这一干预措施的难度。
