Nasio J M, Nagelkerke N J, Mwatha A, Moses S, Ndinya-Achola J O, Plummer F A
Department of Medical Microbiology, University of Nairobi, Kenya.
Int J STD AIDS. 1996 Oct;7(6):410-4. doi: 10.1258/0956462961918374.
In previous studies, genital ulcers in men have been found to be associated with increased risk of HIV-1 seroconversion. To further explore this association male patients attending a sexually transmitted disease (STD) clinic in Nairobi for either urethritis (controls, n = 276) or a genital ulcer (cases, n = 607) were compared with respect to sexual behaviour, presence of HIV-1 antibody and circumcision status. Patients were followed to study risk factors for incident genital ulcers and HIV-1 seroconversion. At entry, being married was associated with higher prevalence of HIV-1 (OR = 1.76) and genital ulcers (OR = 1.42). Lack of circumcision was associated with both HIV-1 infection (OR = 4.67) and the presence of a genital ulcer (OR = 2.23). Genital ulcers were also associated with HIV-1 infection (OR = 1.87) independent of circumcision status. On follow-up, HIV-1 seropositivity was associated with incident genital ulcers. It is argued that the association between genital ulcers and HIV-1 infection may be more complex than ulcers simply being a risk factor for HIV-1 infection, and that HIV-1 infection may either increase the risk of acquiring a genital ulcer, or HIV-1 infection and genital ulcers may have some unknown risk factor in common.
在以往的研究中，已发现男性生殖器溃疡与HIV-1血清阳转风险增加有关。为进一步探究这种关联，对在内罗毕一家性传播疾病（STD）诊所就诊的男性患者进行了比较，其中尿道炎患者（对照组，n = 276）和生殖器溃疡患者（病例组，n = 607）在性行为、HIV-1抗体的存在情况和包皮环切状态方面进行了对比。对患者进行随访以研究新发生殖器溃疡和HIV-1血清阳转的危险因素。在入组时，已婚与HIV-1较高的患病率（OR = 1.76）和生殖器溃疡较高的患病率（OR = 1.42）相关。未进行包皮环切与HIV-1感染（OR = 4.67）和生殖器溃疡的存在（OR = 2.23）均相关。生殖器溃疡也与HIV-1感染相关（OR = 1.87），且与包皮环切状态无关。在随访中，HIV-1血清阳性与新发生殖器溃疡相关。有人认为，生殖器溃疡与HIV-1感染之间的关联可能比溃疡仅仅作为HIV-1感染的一个危险因素更为复杂，并且HIV-1感染可能会增加患生殖器溃疡的风险，或者HIV-1感染和生殖器溃疡可能有一些共同的未知危险因素。
