Farnsworth W E
Invest Urol. 1977 Jul;15(1):75-7.
Evidence of the presence of an androgen-activated "gatekeeper" receptor in the human prostate plasma membrane is presented. Not only does testosterone in vitro very rapidly accelerate uptake of alpha-aminoisobutyric acid into prostate slices but also its metabolite, dihydrotestosterone, greatly increases the rates of phosphorylation and dephosphorylation of the cation-dependent ATPase of isolated membranes. The relationship of this regulatory unit to prostatic physiologic processes is discussed.
本文提供了雄激素激活的“守门人”受体存在于人类前列腺质膜中的证据。体外实验表明，睾酮不仅能非常迅速地加速α-氨基异丁酸进入前列腺切片的摄取，而且其代谢产物双氢睾酮能显著提高分离膜中阳离子依赖性ATP酶的磷酸化和去磷酸化速率。本文还讨论了这个调节单元与前列腺生理过程的关系。
