Deore S M, Supe S J, Sharma V, Dinshaw K A
Department of Medical Physics, Tata Memorial Hospital, Bombay, India.
Strahlenther Onkol. 1991 Oct;167(10):608-11.
The incidence of late complications for different sizes of dose per fraction is analysed in 208 cases with squamous cell carcinoma of the vocal cord. The series comprised 156 cases with T1N0M0 and 52 cases with T2N0M0 lesions. Radical radiotherapy was given with three different regimens having dose per fraction of 3.33 Gy, 2.5 Gy and 2.25 Gy. There were 46 cases of late radiation induced laryngeal oedema. Using this clinical data an alpha/beta value of 2.35 +/- 0.13 Gy was estimated for late complications of the vocal cord. It was found that there is strong correlation between size of dose per fraction and the risk of late complication in the vocal cord.
对208例声带鳞状细胞癌患者不同分次剂量的晚期并发症发生率进行了分析。该系列包括156例T1N0M0病变患者和52例T2N0M0病变患者。采用三种不同的放疗方案进行根治性放疗，分次剂量分别为3.33 Gy、2.5 Gy和2.25 Gy。有46例发生晚期放射性喉水肿。利用该临床数据，估计声带晚期并发症的α/β值为2.35±0.13 Gy。发现分次剂量大小与声带晚期并发症风险之间存在强相关性。
