Deore S M, Supe S J, Sharma V, Dinshaw K A
Dept. of Med. Physics, BARC, Bombay, India.
Indian J Cancer. 1993 Sep;30(3):113-9.
The incidence of late complications for different size of dose per fraction is analysed in 208 cases with squamous cell carcinoma of the vocal cord. The series comprised 156 cases with T1 and 52 cases with T2 lesions. Radical radiotherapy was given with three different regimens having dose per fraction as 3.33, 2.5 and 2.25 Gy. There were 46 cases with persisting radiation induced laryngeal oedema. Using two different statistical methods, an alpha/beta value of 2.38 Gy of linear quadratic model was estimated for late complications of vocal cord. The analysis indicate the increased incidence of late complications with size of dose per fraction. Relevance of linear quadratic model for the prediction of late complication is demonstrated in the present study.
对208例声带鳞状细胞癌患者不同分次剂量的晚期并发症发生率进行了分析。该系列包括156例T1期病变和52例T2期病变。采用三种不同方案进行根治性放疗，分次剂量分别为3.33、2.5和2.25 Gy。有46例出现持续性放射性喉水肿。采用两种不同的统计方法，估计声带晚期并发症的线性二次模型的α/β值为2.38 Gy。分析表明，晚期并发症的发生率随分次剂量大小的增加而增加。本研究证明了线性二次模型对晚期并发症预测的相关性。
