Research Centre for Prion Diseases, University of Zaragoza, Spain.
Zoonoses Public Health. 2010 Aug;57(5):358-66. doi: 10.1111/j.1863-2378.2009.01230.x. Epub 2009 Apr 8.
Environmental exposure to metal appears to enhance susceptibility to Transmissible Spongiform Encephalopathies (TSEs); however, published data are not conclusive. The current study focuses on assessing the effects of copper depletion and/or manganese enhancement in the diet on susceptibility to Scrapie and this disease progression. The degree of spongiosis was the highest in the animals that received a copper- depleted diet. These observations suggest that this diet contributes to the Scrapie lesions and to the worsening of the condition in animals that have been inoculated with Scrapie. The highest intensities of GFAP immunostaining were also associated with the copper- depleted diet. Dietary supplementation with manganese had a negative effect on neuronal counts. In conclusion, this study demonstrates that certain environmental factors may aggravate neuropathological Scrapie lesions. This is consistent with reports from other neurodegenerative diseases where some metalloenzymes play a pivotal protector role against the oxidative stress associated with pathogenesis.
环境暴露于金属似乎会增加对传染性海绵状脑病（TSE）的易感性；然而，已发表的数据并不具有结论性。本研究重点评估饮食中铜耗竭和/或锰增强对瘙痒病易感性和疾病进展的影响。在接受铜耗竭饮食的动物中，海绵状变性的程度最高。这些观察结果表明，这种饮食会导致瘙痒病病变，并使已接种瘙痒病的动物病情恶化。GFAP 免疫染色的最高强度也与铜耗竭饮食有关。膳食补充锰对神经元计数有负面影响。总之，这项研究表明，某些环境因素可能会加重神经病理学瘙痒病病变。这与其他神经退行性疾病的报告一致，其中一些金属酶在对抗与发病机制相关的氧化应激方面发挥关键的保护作用。
