Meng Bo, Zhu Shujia, Li Shijia, Zeng Qingwen, Mei Bing
Key Lab of Brain Functional Genomics, MOE & STCSM, Shanghai Institute of Brain Functional Genomics, East China Normal University, 3663 North Zhongshan Road, Shanghai, China.
Brain Res Bull. 2009 Aug 28;80(1-2):36-44. doi: 10.1016/j.brainresbull.2009.05.020. Epub 2009 May 30.
Music has been proved beneficial to improve learning and memory in many species including human in previous research work. Although some genes have been identified to contribute to the mechanisms, it is believed that the effect of music is manifold, behind which must concern a complex regulation network. To further understand the mechanisms, we exposed the mice to classical music for one month. The subsequent behavioral experiments showed improvement of spatial learning capability and elevation of fear-motivated memory in the mice with music-exposure as compared to the naïve mice. Meanwhile, we applied the microarray to compare the gene expression profiles of the hippocampus and cortex between the mice with music-exposure and the naïve mice. The results showed approximately 454 genes in cortex (200 genes up-regulated and 254 genes down-regulated) and 437 genes in hippocampus (256 genes up-regulated and 181 genes down-regulated) were significantly affected in music-exposing mice, which mainly involved in ion channel activity and/or synaptic transmission, cytoskeleton, development, transcription, hormone activity. Our work may provide some hints for better understanding the effects of music on learning and memory.
在以往的研究工作中，音乐已被证明有利于提高包括人类在内的许多物种的学习和记忆能力。尽管已确定一些基因有助于这些机制，但人们认为音乐的影响是多方面的，其背后必定涉及一个复杂的调控网络。为了进一步了解这些机制，我们让小鼠接触古典音乐达一个月之久。随后的行为实验表明，与未接触音乐的小鼠相比，接触音乐的小鼠的空间学习能力有所提高，恐惧动机记忆增强。同时，我们应用微阵列技术比较了接触音乐的小鼠和未接触音乐的小鼠海马体和皮质的基因表达谱。结果显示，在接触音乐的小鼠中，皮质中约454个基因（200个基因上调，254个基因下调）和海马体中437个基因（256个基因上调，181个基因下调）受到显著影响，这些基因主要涉及离子通道活性和/或突触传递、细胞骨架、发育、转录、激素活性。我们的工作可能为更好地理解音乐对学习和记忆的影响提供一些线索。
