UCL Ear Institute, University College London, London, UK.
Translational and Clinical Research Institute, Newcastle University Medical School, Newcastle upon Tyne, UK.
Prog Neurobiol. 2022 Nov;218:102326. doi: 10.1016/j.pneurobio.2022.102326. Epub 2022 Jul 21.
The hippocampus has a well-established role in spatial and episodic memory but a broader function has been proposed including aspects of perception and relational processing. Neural bases of sound analysis have been described in the pathway to auditory cortex, but wider networks supporting auditory cognition are still being established. We review what is known about the role of the hippocampus in processing auditory information, and how the hippocampus itself is shaped by sound. In examining imaging, recording, and lesion studies in species from rodents to humans, we uncover a hierarchy of hippocampal responses to sound including during passive exposure, active listening, and the learning of associations between sounds and other stimuli. We describe how the hippocampus' connectivity and computational architecture allow it to track and manipulate auditory information - whether in the form of speech, music, or environmental, emotional, or phantom sounds. Functional and structural correlates of auditory experience are also identified. The extent of auditory-hippocampal interactions is consistent with the view that the hippocampus makes broad contributions to perception and cognition, beyond spatial and episodic memory. More deeply understanding these interactions may unlock applications including entraining hippocampal rhythms to support cognition, and intervening in links between hearing loss and dementia.
海马体在空间和情景记忆方面具有明确的作用，但也有人提出了更广泛的功能，包括感知和关系处理方面。听觉皮层的通路中已经描述了声音分析的神经基础，但支持听觉认知的更广泛的网络仍在建立中。我们回顾了海马体在处理听觉信息中的作用，以及声音如何塑造海马体本身。通过检查从啮齿动物到人类等物种的成像、记录和损伤研究，我们发现了海马体对声音的反应层次，包括在被动暴露、主动聆听以及声音与其他刺激之间的关联学习期间的反应。我们描述了海马体的连接和计算结构如何允许它跟踪和操纵听觉信息——无论是言语、音乐还是环境、情感或幻听的形式。还确定了听觉体验的功能和结构相关性。听觉-海马体相互作用的程度与海马体对感知和认知的广泛贡献一致，而不仅仅是空间和情景记忆。更深入地了解这些相互作用可能会解锁包括使海马体节律同步以支持认知，以及干预听力损失和痴呆之间联系的应用。
