Rogol Alan D
Riley Hospital, Indiana University School of Medicine, Indianapolis, IN, United States.
Growth Horm IGF Res. 2009 Aug;19(4):294-9. doi: 10.1016/j.ghir.2009.04.007. Epub 2009 May 31.
There is great interest among athletes and in the sports and general media for the subject of "doping" with human growth hormone (hGH). The hype about this substance goes far beyond the available data. The issue of administration of recombinant rhGH to adolescents, whether for athletic performance or for esthetic purposes adds another wrinkle because normal pubertal growth and the acquisition of adult body composition depends upon the GH/IGF-I and the hypothalamic-pituitary-gonadal axes. The range of normal is wide and it is more difficult to determine the natural evolution of pubertal development from that fueled by rhGH (or anabolic steroids). There are no compelling data based on clinical trials to indicate enhanced athletic performance (young adults); however, one cannot be sure how rhGH is used in combination with other agents, including anabolic steroids and anabolic "supplements". There are no studies in adolescent athletes. The detection of administration of rhGH to adolescents using the analytes of the GH/IGF-I and of collagen turnover (bone modeling and remodeling) is complicated by the physiologic increases in these parameters during normal puberty. It should be noted that many older adolescents are physiologically younger, especially in those aesthetic sports that demand the thin (linear) physique.
运动员以及体育和大众媒体对使用人生长激素（hGH）进行“兴奋剂”相关话题极为关注。关于这种物质的炒作远远超出了现有数据。给青少年使用重组人生长激素（rhGH）的问题，无论是为了提高运动成绩还是出于美容目的，都增添了另一个复杂因素，因为正常的青春期生长以及成年身体成分的形成依赖于生长激素/胰岛素样生长因子 -I（GH/IGF-I）轴和下丘脑 - 垂体 - 性腺轴。正常范围很广，因此更难区分由rhGH（或合成代谢类固醇）推动的青春期发育与自然发育过程。基于临床试验，尚无令人信服的数据表明（年轻成年人）运动成绩会因此提高；然而，无法确定rhGH与其他药物（包括合成代谢类固醇和合成代谢“补充剂”）联合使用的情况。目前尚无针对青少年运动员的研究。利用GH/IGF-I分析物以及胶原蛋白更新（骨骼塑形和重塑）来检测青少年是否使用rhGH，因这些参数在正常青春期会生理性增加而变得复杂。应当指出，许多年龄较大的青少年在生理上更为年轻，尤其是在那些要求身材苗条（体型修长）的审美性运动项目中。
