Gordeev A V, Sura V V, Savitskiĭ S N
Ter Arkh. 1991;63(6):43-6.
Eighteen patients with senile pyelonephritis and nephrogenic arterial hypertension were examined for the effect of trental monotherapy (600 mg/day) on intrarenal hemodynamics, the rate of glomerular filtration (effective renal blood flow, the intensity of blood flow in the medullary layer of the kidney), activity of the renin-angiotensin-aldosterone system (plasma renin activity, plasma and urine aldosterone), prostaglandin synthetic capacity of the kidneys (PGE and PGF2 alpha), water-electrolyte balance (circulating blood volume, sodium content in the serum and its excretion with urine), and on arterial pressure and general vascular peripheral resistance. Prolonged administration of the drug (from 3 weeks to 6 months) led to a significant improvement of the medullary blood flow, increase (p less than or equal to 0.05) of excretion of natriuretic PGE [correction of RGE] and lowering (p less than or equal to 0.05) of diurnal excretion of PGF2 alpha, which was accompanied by a rise of natriuresis (p less than or equal to 0.05) and diuresis.
对18例患有老年性肾盂肾炎和肾性动脉高血压的患者进行了检查，以观察曲克芦丁单一疗法（600毫克/天）对肾内血流动力学、肾小球滤过率（有效肾血流量、肾髓质层血流强度）、肾素-血管紧张素-醛固酮系统活性（血浆肾素活性、血浆和尿液醛固酮）、肾脏前列腺素合成能力（前列腺素E和前列腺素F2α）、水电解质平衡（循环血容量、血清钠含量及其尿排泄量）以及动脉血压和全身血管外周阻力的影响。长期给药（3周至6个月）导致髓质血流显著改善，利钠前列腺素E排泄增加（p≤0.05），前列腺素F₂α日排泄量降低（p≤0.05），同时伴有钠利尿（p≤0.05）和利尿增加。
