Heinemann Lutz, Nosek Leszek, Kapitza Christoph, Schweitzer Matthias-Axel, Krinelke Lars
Profil Institut für Stoffwechselforschung GmbH, Neuss, Germany.
Diabetes Care. 2009 Aug;32(8):1437-9. doi: 10.2337/dc09-0595. Epub 2009 Jun 1.
OBJECTIVE Evaluation of the time required until a change in the basal insulin infusion rate with an insulin pump induces subsequent changes in the metabolic effect. RESEARCH DESIGN AND METHODS In this euglycemic glucose clamp study, 10 male subjects with type 1 diabetes received three different subcutaneous insulin infusion rates (0.5, 1.0, and 2.0 units/h; for 4 h each) of insulin lispro (IL) with insulin pumps. RESULTS An increase in insulinemia occurred within 15-30 min after changing the infusion rate. While the serum IL levels reached a steady state at the end of the infusion period, the glucose infusion rates did not always reach steady-state levels with the higher infusion rates. However, an increase in the glucose consumption occurred within 30-60 min after switching the infusion rate. CONCLUSIONS Several hours are required until a new steady state in the metabolic effect is achieved after a significant change in basal insulin infusion.
目的 评估胰岛素泵基础胰岛素输注速率发生变化直至引起后续代谢效应改变所需的时间。研究设计与方法 在这项正常血糖葡萄糖钳夹研究中，10名1型糖尿病男性受试者通过胰岛素泵接受三种不同的皮下胰岛素输注速率（0.5、1.0和2.0单位/小时；每种输注4小时）的赖脯胰岛素（IL）。结果 改变输注速率后15 - 30分钟内出现胰岛素血症增加。虽然输注期结束时血清IL水平达到稳态，但较高输注速率下葡萄糖输注速率并非总能达到稳态水平。然而，切换输注速率后30 - 60分钟内葡萄糖消耗增加。结论 基础胰岛素输注发生显著变化后，需要数小时才能达到代谢效应的新稳态。
