Saeed Sahrai, Vegsundvåg Johnny, Lode Inge
Medisinsk avdeling, Alesund sjukehus, 6026 Alesund.
Tidsskr Nor Laegeforen. 2009 May 28;129(11):1104-7. doi: 10.4045/tidsskr.08.0077.
Noncompaction of the left ventricular myocardium is recently described as a cause of left ventricular dysfunction. In the article, we describe epidemiological and clinical aspects of this condition, which presents clinically at any age.
This article is based on a review of articles from our own literature archive and relevant references in these articles.
Ventricular noncompaction results from an arrest in the normal endomyocardial embryogenesis, and often leads to heart failure, thrombo-embolic events and/or ventricular arrhythmias. The disorder is diagnosed by two-dimensional echocardiography or magnetic resonance imaging of the heart. The changes are typically seen in the apex and distal and middle segments of the inferior and lateral walls of the left ventricle. The affected segments of the myocardium have a two-layered structure: a compacted thin epicardial layer and an endocardial layer consisting of a prominent trabecular meshwork with deep intertrabecular spaces. The condition can be isolated with or without extracardiac disorders, or can be associated with other cardiac malformations.
It is essential not to miss the findings of noncompaction, as the condition may lead to serious heart failure, thrombo-embolic events, ventricular tachyarrythmias or death. Early recognition of noncompaction may give better follow-up and management of patients with this condition.
左心室心肌致密化不全最近被描述为左心室功能障碍的一个原因。在本文中，我们描述了这种在任何年龄均可临床呈现的病症的流行病学和临床特征。
本文基于对我们自己文献档案中的文章以及这些文章中的相关参考文献的综述。
心室致密化不全是由于正常心内膜胚胎发育停滞所致，常导致心力衰竭、血栓栓塞事件和/或室性心律失常。该病症通过心脏二维超声心动图或磁共振成像诊断。这些改变通常见于左心室心尖部以及下壁和侧壁的远端及中间节段。心肌的受累节段具有双层结构：一层致密的薄心外膜层和一层由突出的小梁网状结构及深陷的小梁间隙组成的心内膜层。该病症可孤立存在，伴或不伴有心外疾病，也可与其他心脏畸形相关。
务必不能漏诊致密化不全的表现，因为该病症可能导致严重心力衰竭、血栓栓塞事件、室性快速心律失常或死亡。早期识别致密化不全可为患有该病症的患者提供更好的随访和管理。
