Iversen O E, Eid A B, Johannesen K H, Nyland B, Løvset T
Kvinneklinikken, Haukeland sykehus, Bergen.
Tidsskr Nor Laegeforen. 1991 Aug 30;111(20):2544-6.
A double blind, crossover study was used to test the effect of transdermal oestrogen therapy (Estraderm) in 22 women with climacteric complaints. The number and intensity of hot flushes were both reduced by approximately 80% (p less than 0.0025). Some improvement was also seen as regards general wellbeing, disturbed sleep and tiredness. We noted a significant increase in serum oestradiol to premenopausal follicular phase levels, and a decrease in FSH values. Systolic blood pressure was lowered during active treatment (p less than 0.025), a smaller reduction of diastolic pressure was not significant. Body weight remained unchanged. Some patients reported tender breasts, and some reported slight irritation of the skin. Neither condition necessitated withdrawal of treatment. It is concluded that Estraderm is effective and suitable for treatment of climacteric complaints.
采用双盲交叉研究来测试经皮雌激素疗法（雌二醇贴片）对22名有更年期症状女性的疗效。潮热的次数和强度均降低了约80%（p<0.0025）。在总体健康状况、睡眠障碍和疲劳方面也有一些改善。我们注意到血清雌二醇显著升高至绝经前卵泡期水平，促卵泡生成素值降低。在积极治疗期间收缩压降低（p<0.025），舒张压较小幅度的降低不显著。体重保持不变。一些患者报告有乳房胀痛，一些患者报告有皮肤轻微刺激。两种情况均无需停止治疗。结论是雌二醇贴片对治疗更年期症状有效且适用。
