Department of Internal Medicine, Section of Endocrinology and Metabolism, Yeditepe University Hospital, Devlet Yolu Ankara Cad. No: 102, Kozyatagi, Istanbul, 34752, Turkey.
Biol Trace Elem Res. 2010 Feb;133(2):136-43. doi: 10.1007/s12011-009-8416-8. Epub 2009 Jun 2.
Magnesium has been shown to increase bone mineral density when used in the treatment of osteoporosis, yet its mechanism of action is obscure. In this study, the effects of daily oral magnesium supplementation on biochemical markers of bone turnover were investigated. Twenty postmenopausal women have been divided into two groups. Ten patients were given magnesium citrate (1,830 mg/day) orally for 30 days. Ten postmenopausal women of matching age, menopause duration, and BMI were recruited as the control group and followed without any medication. Fasting blood and first-void urine samples were collected on days 0, 1, 5, 10, 20, and 30, respectively. Total magnesium, calcium, phosphorus, iPTH and osteocalcin were determined in blood samples. Deoxypyridinoline levels adjusted for creatinine were measured in urine samples. Thirty consecutive days of oral magnesium supplementation caused significantly decrease in serum iPTH levels in the Mg-supplemented group (p < 0.05). Serum osteocalcin levels were significantly increased (p < 0.001) and urinary deoxypyridinoline levels were decreased (p < 0.001) in the Mg-supplemented group. This study has demonstrated that oral magnesium supplementation in postmenopausal osteoporotic women suppresses bone turnover.
镁已被证明可增加骨质疏松症治疗中的骨矿物质密度，但作用机制尚不清楚。在这项研究中，我们研究了每日口服镁补充剂对骨转换生化标志物的影响。将 20 名绝经后妇女分为两组。10 名患者口服柠檬酸镁（1830mg/天），连续 30 天。10 名年龄、绝经时间和 BMI 匹配的绝经后妇女作为对照组，不服用任何药物进行随访。分别在第 0、1、5、10、20 和 30 天采集空腹血和首次晨尿样本。测定血样中的总镁、钙、磷、iPTH 和骨钙素。尿样中测定脱氧吡啶啉水平并进行肌酐校正。连续 30 天口服镁补充剂可使补充镁组的血清 iPTH 水平显著降低（p < 0.05）。补充镁组的血清骨钙素水平显著升高（p < 0.001），尿脱氧吡啶啉水平降低（p < 0.001）。本研究表明，绝经后骨质疏松妇女口服镁补充剂可抑制骨转换。
