Olusanya Bolajoko O, Afe Abayomi J, Solanke Olumuyiwa A
Department of Community Health and Primary Care, University of Lagos, Nigeria.
J Matern Fetal Neonatal Med. 2009 Jul;22(7):576-83. doi: 10.1080/14767050902906360.
To determine associated risk factors for stillbirths in Lagos, Nigeria and to examine possible relationships between these factors and the risk of sensorineural hearing loss (SNHL).
Stillbirths in an inner-city maternity hospital from June 2005 to May 2007 were matched with live-birth controls at ratio 1:2. Risk factors and their associated adjusted odds ratio (OR) at 95% confidence interval (CI) were first determined by multiple logistic regression and then correlated with hearing screening failure among survivors who received a two-stage hearing screening with automated otoacoustic emissions and auditory brainstem response.
Of 201 cases examined and matched with 402 live births, 101 (50.2%) were fresh stillbirths and 100 (49.8%) macerated. Multiparity (OR: 1.92; CI: 1.16-3.20), lack of antenatal care (OR: 7.23; CI: 3.94-13.26), hypertensive conditions (OR: 6.48; CI: 2.94-14.29), antepartum haemorrhage (OR:18.84; CI: 6.96-51.00), premature rupture of membrane (OR:3.36; CI: 1.40-8.05), prolonged obstructed labour (OR: 22.25; CI: 10.07-49.16) and prematurity (OR: 2.30; CI: 1.2-4.01) were associated with increased risk of stillbirths whereas caesarean section (OR: 0.24; CI: 0.12-0.48) was associated with lower risk of stillbirths. Infants delivered by mothers with hypertensive conditions during pregnancy were at risk of SNHL (OR: 2.97; CI: 1.15-7.64).
Hypertensive conditions during pregnancy increase the risk of stillbirths and place survivors at greater risk of SNHL.
确定尼日利亚拉各斯死产的相关危险因素，并研究这些因素与感音神经性听力损失（SNHL）风险之间的可能关系。
将2005年6月至2007年5月间一家市中心妇产医院的死产病例与活产对照按1:2的比例进行匹配。首先通过多因素逻辑回归确定危险因素及其在95%置信区间（CI）的相关调整比值比（OR），然后将其与接受自动耳声发射和听性脑干反应两阶段听力筛查的幸存者中听力筛查未通过情况进行关联分析。
在201例接受检查并与402例活产匹配的病例中，101例（50.2%）为新鲜死产，100例（49.8%）为浸软死产。多产（OR：1.92；CI：1.16 - 3.20）、缺乏产前护理（OR：7.23；CI：3.94 - 13.26）、高血压疾病（OR：6.48；CI：2.94 - 14.29）、产前出血（OR：18.84；CI：6.96 - 51.00）、胎膜早破（OR：3.36；CI：1.40 - 8.05）、产程延长梗阻（OR：22.25；CI：10.07 - 49.16）和早产（OR：2.30；CI：1.2 - 4.01）与死产风险增加相关，而剖宫产（OR：0.24；CI：0.12 - 0.48）与死产风险降低相关。孕期患有高血压疾病的母亲所分娩的婴儿有患SNHL的风险（OR：2.97；CI：1.15 - 7.64）。
孕期高血压疾病会增加死产风险，并使幸存者患SNHL的风险更高。
