Changes in phospholipid composition of synaptic membranes in frontal lobes of cerebral hemispheres in cats at various stages of hemorrhagic shock.

Phospholipid composition of synaptic membranes in the frontal lobes of cerebral hemispheres was studied in cats with hemorrhagic shock. The compensatory and adaptive mechanisms of regulation of neurotransmission in this region of the brain at the initial stage of hemorrhagic shock are associated with increased degradation of phosphatidylinositol. Accumulation of this phospholipid in synaptic membranes during severe hemorrhagic shock reflects instability of the key neuroregulatory pathway, which is mediated by phosphatidylinositol metabolites. Dysregulation of transmembrane signaling in hemorrhagic shock is related to depletion of phosphatidylcholine and phosphatidylserine in synaptic membranes and accumulation of phosphatidylethanolamine.