Sun G Y, Sun A Y
Biochem Biophys Res Commun. 1983 May 31;113(1):262-8. doi: 10.1016/0006-291x(83)90460-6.
Chronic ethanol administration to guinea pigs via intragastric intubation elicited a specific increase (50%) in phosphatidylserine in the synaptic plasma membrane. The ethanol-treated group also showed a 53% increase in synaptosomal (Na,K)-ATPase activity. Analysis of the acyl group composition of individual phospholipids in the same membrane fraction revealed only small changes which varied depending on the type of phospholipids. Since the (Na,K)-ATPase is known to be specifically activated by phosphatidylserine, the adaptive increase in enzyme activity during chronic ethanol treatment may be related to the increase in this type of negatively charged phospholipid.
通过胃内插管对豚鼠进行慢性乙醇给药，引发了突触质膜中磷脂酰丝氨酸的特异性增加（50%）。乙醇处理组的突触体（Na，K）-ATP酶活性也增加了53%。对同一膜组分中单个磷脂的酰基组成分析表明，只有微小变化，且这些变化因磷脂类型而异。由于已知（Na，K）-ATP酶可被磷脂酰丝氨酸特异性激活，慢性乙醇处理期间酶活性的适应性增加可能与这种带负电荷的磷脂增加有关。
