Gilhus N E
Nevrologisk avdeling, Haukeland sykehus, Bergen.
Tidsskr Nor Laegeforen. 1991 Oct 30;111(26):3166-9.
28 patients with parkinsonism received the dopamine agonist drug apomorphine for the period August 1990-August 1991. Treatment with repeated subcutaneous injections was started in 13 patients who had suffered from Parkinson's disease for more than ten years. All patients received optimal levodopa treatment. Apomorphine had a very good effect in eight patients; i.e. the time in offphase was markedly reduced. This very good effect was seen only in patients with marked on-off phenomena and usually end of dose failure. The patients who experienced the best effect had little dyskinesias during on-phase and were not mentally affected. An additional 15 patients were given apomorphine for diagnostic purposes. Following a positive test, levodopa treatment was started in one patient and the levodopa dose was increased in two others. In the remaining patients the apomorphine test was negative, and levodopa treatment was not reinstituted.
1990年8月至1991年8月期间，28例帕金森病患者接受了多巴胺激动剂阿扑吗啡治疗。13例患帕金森病超过10年的患者开始接受重复皮下注射治疗。所有患者均接受了最佳的左旋多巴治疗。阿扑吗啡对8例患者有非常好的效果，即关期时间明显缩短。这种非常好的效果仅在有明显开关现象且通常存在剂末失效的患者中出现。效果最佳的患者在开期几乎没有异动症，且未出现精神方面的影响。另外15例患者接受阿扑吗啡用于诊断目的。试验结果呈阳性后，1例患者开始接受左旋多巴治疗，另外2例患者增加了左旋多巴剂量。其余患者阿扑吗啡试验为阴性，未重新开始左旋多巴治疗。
