Yen Ching-Yu, Chen Chung-Ho, Chang Chao-Hsiang, Tseng Hung-Fu, Liu Shyun-Yeu, Chuang Li-Yeh, Wen Cheng-Hao, Chang Hsueh-Wei
Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Tainan, Taiwan.
Biomarkers. 2009 Jun;14(4):244-9. doi: 10.1080/13547500902829375.
The aim of this study was to investigate the mRNA performance of matrix metalloproteinases (MMP) 1, MMP10 and MMP12 as oral cancer markers. With gingiva as the control, the areas under the receiver- operating characteristic curves (AUCs) of the relative gene expressions for MMP1, MMP10 and MMP12 were 0.715, 0.727 and 0.513, respectively. With the margins or neck platysma muscles as controls, the AUCs of MMP1, MMP10 and MMP12 were 0.746 vs 0.626, 0.712 vs 0.683 and 0.697 vs 0.630, respectively. MMP10 displayed the best sensitivity for oral cancer detection with any controls. MMP1 and MMP10 were suitable markers for cancer detection with gingiva and margin as controls. Using neck tissue as the control, only MMP10 was suitable for cancer detection. With margin and neck controls, there were no significant differences for MMP1, MMP10 and MMP12 in different stages, invasion and locations or different habits. Therefore, MMP1 and MMP10 but not MMP12 are potential oral cancer markers.
本研究旨在调查基质金属蛋白酶（MMP）1、MMP10和MMP12作为口腔癌标志物的mRNA表现。以牙龈为对照，MMP1、MMP10和MMP12相对基因表达的受试者工作特征曲线下面积（AUC）分别为0.715、0.727和0.513。以切缘或颈部颈阔肌为对照，MMP1、MMP10和MMP12的AUC分别为0.746对0.626、0.712对0.683和0.697对0.630。在任何对照下，MMP10对口腔癌检测表现出最佳敏感性。以牙龈和切缘为对照时，MMP1和MMP10是癌症检测的合适标志物。以颈部组织为对照时，只有MMP10适用于癌症检测。以切缘和颈部为对照时，MMP1、MMP10和MMP12在不同阶段、侵袭情况、位置或不同习惯方面无显著差异。因此，MMP1和MMP10而非MMP12是潜在的口腔癌标志物。
