波兰人群中基质金属蛋白酶1、基质金属蛋白酶3、基质金属蛋白酶9和基质金属蛋白酶12基因多态性与多发性硬化症风险及临床病程的关联
Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.
作者信息
Mirowska-Guzel Dagmara, Gromadzka Grazyna, Czlonkowski Andrzej, Czlonkowska Anna
机构信息
2nd Department of Neurology, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland.
出版信息
J Neuroimmunol. 2009 Sep 29;214(1-2):113-7. doi: 10.1016/j.jneuroim.2009.06.014. Epub 2009 Jul 22.
Single nucleotide polymorphisms in human MMP genes, including MMP1 (-1637 1G>2G), MMP3 (-1612 5A>6A), MMP9 (-1562 C>T), and MMP12 (-82 A>G), and their impact on multiple sclerosis risk and disease progression in a Polish population were investigated. Increased risk of MS was found among carriers of at least one T allele of MMP9 -1562 C>T (OR, 1.7; p=0.0030) and one G allele of MMP12 -82 A>G (OR, 3.9; p<0.00001). Additionally, an association between MMP9 genotype and MMP-9 levels in peripheral blood was detected. Our results suggest that MMP9 -1562 C>T and MMP12 -82 A>G polymorphisms affect susceptibility to multiple sclerosis.
对人类基质金属蛋白酶（MMP）基因中的单核苷酸多态性进行了研究，这些基因包括MMP1（-1637 1G>2G）、MMP3（-1612 5A>6A）、MMP9（-1562 C>T）和MMP12（-82 A>G），及其对波兰人群中多发性硬化症风险和疾病进展的影响。在MMP9 -1562 C>T至少携带一个T等位基因的携带者（比值比[OR]，1.7；p = 0.0030）和MMP12 -82 A>G至少携带一个G等位基因的携带者（OR，3.9；p<0.00001）中发现多发性硬化症风险增加。此外，还检测到MMP9基因型与外周血中MMP-9水平之间存在关联。我们的结果表明，MMP9 -1562 C>T和MMP12 -82 A>G多态性影响对多发性硬化症的易感性。
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