Laboratoire des adaptations cardiocirculatoires, respiratoires, métaboliques et hormonales à l'exercice musculaire, faculté de médecine Ibn El Jazzar, avenue Mohamed-Karoui, 4002 Sousse, Tunisie.
Ann Endocrinol (Paris). 2009 Sep;70(4):235-41. doi: 10.1016/j.ando.2009.03.003. Epub 2009 Apr 28.
To examine if, in young obese patients, an individualized training programme in association with a caloric restriction programme which had an effect on whole-body lipid oxidation, was able to induce changes on plasma adipocytokine concentrations.
Twenty-seven obese female adolescents participated in the study. Whole-body lipid oxidation during exercise was assessed by indirect calorimetry during a graded cycle ergometer test. Body mass (BM), body mass index (BMI), percentage of body fat (%BF), insulin homeostasis model assessment (HOMA-IR) and fasting levels of circulating adipocytokines were assessed prior and after a two-month diet programme, individualized training programme targeted at Lipox(max) corresponded to the power at which the highest rate of lipids was oxidized and combined diet/training programme.
The diet/training programme induced both a shift to a higher-power intensity of Lipox(max) (+27.8 + or - 5.1 W; p<0.01) and an increase of lipid oxidation at Lipox(max) (+96.8 + or - 16.2mg/min; p<0.01). The enhancement in lipid oxidation was significantly (p<0.01) correlated with the diet/training-induced improvement in %BF (r = -0.47), HOMA-IR (r = -0.66), leptin (r = -0.41), TNF-alpha (r = -0.48), IL-6 (r = -0.38), adiponectin (r = 0.43) and resistin (r = 0.51).
This study showed that in obese female adolescents a moderate training protocol targeted at Lipox(max) and combined with a diet programme improved their ability to oxidize lipids during exercise, and that this improvement was associated with changes in plasma adipocytokine concentrations.
研究在年轻肥胖患者中，与全身性脂质氧化作用相关的个体化训练方案与热量限制方案联合作用，是否能够引起血浆脂肪细胞因子浓度的变化。
27 名肥胖的年轻女性参与了本研究。通过递增式踏车运动试验中的间接测热法评估运动时的全身脂质氧化作用。在为期两个月的饮食方案、个体化训练方案（以脂质氧化最大值时的功率为目标，即脂质氧化率最高时的功率）和联合饮食/训练方案之前和之后评估了体重（BM）、体重指数（BMI）、体脂百分比（%BF）、胰岛素稳态模型评估（HOMA-IR）和循环脂肪细胞因子的空腹水平。
饮食/训练方案引起了脂质氧化最大值的功率强度（Lipox(max)）向更高强度的转变（+27.8 ± 5.1 W；p<0.01）和 Lipox(max)时脂质氧化的增加（+96.8 ± 16.2 mg/min；p<0.01）。脂质氧化的增强与饮食/训练方案引起的体脂百分比（%BF）改善（r = -0.47）、HOMA-IR（r = -0.66）、瘦素（r = -0.41）、TNF-α（r = -0.48）、IL-6（r = -0.38）、脂联素（r = 0.43）和抵抗素（r = 0.51）的改善显著相关（p<0.01）。
本研究表明，在肥胖的年轻女性中，针对脂质氧化最大值的适度训练方案与饮食方案相结合可提高其运动时的脂质氧化能力，并且这种改善与血浆脂肪细胞因子浓度的变化相关。
