多个碱性残基在确定环磷酸腺苷依赖性蛋白激酶底物特异性中的作用。 - Suppr

Suppr

超能文献

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase.

作者信息

Kemp B E, Graves D J, Benjamini E, Krebs E G

出版信息

J Biol Chem. 1977 Jul 25;252(14):4888-94.

PMID:194899

Abstract

摘要

相似文献

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase.多个碱性残基在确定环磷酸腺苷依赖性蛋白激酶底物特异性中的作用。

J Biol Chem. 1977 Jul 25;252(14):4888-94.

Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic AMP-dependent protein kinase.3',5'-环磷酸腺苷依赖性蛋白激酶的合成六肽底物和抑制剂。

Proc Natl Acad Sci U S A. 1976 Apr;73(4):1038-42. doi: 10.1073/pnas.73.4.1038.

Inhibition of cyclic AMP-dependent protein kinase by analogues of a synthetic peptide substrate.合成肽底物类似物对环磷酸腺苷依赖性蛋白激酶的抑制作用。

J Biol Chem. 1978 Dec 25;253(24):8968-71.

Synthetic substrate for cyclic AMP-dependent protein kinase.环磷酸腺苷依赖性蛋白激酶的合成底物。

Nature. 1975 Oct 2;257(5525):416-8. doi: 10.1038/257416a0.

Phosphorylation of threonine and serine residues of native and partially dephosphorylated caseins by a rat liver cyclic AMP-insensitive protein kinase.大鼠肝脏环磷酸腺苷不敏感蛋白激酶对天然和部分去磷酸化酪蛋白苏氨酸和丝氨酸残基的磷酸化作用

Biochem J. 1979 Jun 1;179(3):693-6. doi: 10.1042/bj1790693.

Purification and properties of a cyclic AMP-independent protein kinase from calf thymus nuclei.来自小牛胸腺细胞核的一种不依赖环磷酸腺苷的蛋白激酶的纯化及性质

Biochim Biophys Acta. 1978 Feb 16;517(2):447-56. doi: 10.1016/0005-2787(78)90211-3.

Comparison of substrate specificity of myosin kinase and cyclic AMP-dependent protein kinase.肌球蛋白激酶与环磷酸腺苷依赖性蛋白激酶底物特异性的比较。

Biochim Biophys Acta. 1984 May 17;786(3):261-6. doi: 10.1016/0167-4838(84)90096-7.

The minimum substrate of cyclic AMP-stimulated protein kinase, as studied by synthetic peptides representing the phosphorylatable site of pyruvate kinase (type L) of rat liver.

Biochem Biophys Res Commun. 1976 Jun 7;70(3):696-703. doi: 10.1016/0006-291x(76)90648-3.

Evaluation of kemptide, a synthetic serine-containing heptapeptide, as a phosphate acceptor for the estimation of cyclic AMP-dependent protein kinase activity in respiratory tissues.评估肯普肽（一种合成的含丝氨酸七肽）作为磷酸受体在测定呼吸组织中环磷酸腺苷依赖性蛋白激酶活性方面的作用。

Biochem Pharmacol. 1990 Jan 15;39(2):271-83. doi: 10.1016/0006-2952(90)90026-h.

Identification of the residues on cyclic GMP-dependent protein kinase that are autophosphorylated in the presence of cyclic AMP and cyclic GMP.

Biochim Biophys Acta. 1984 Nov 9;790(3):219-25. doi: 10.1016/0167-4838(84)90025-6.

引用本文的文献

Kinase Mobility Shift Assay (KiMSA) for Assessing Protein Kinase A Activity.用于评估蛋白激酶A活性的激酶迁移率变动分析（KiMSA）

Bio Protoc. 2025 Jul 5;15(13):e5366. doi: 10.21769/BioProtoc.5366.

AMPK phosphosite profiling by label-free mass spectrometry reveals a multitude of mTORC1-regulated substrates.通过无标记质谱法进行的AMPK磷酸化位点分析揭示了众多受mTORC1调节的底物。

NPJ Metab Health Dis. 2025;3(1):8. doi: 10.1038/s44324-025-00052-7. Epub 2025 Mar 4.

Crystallographic, kinetic, and calorimetric investigation of PKA interactions with L-type calcium channels and Rad GTPase.蛋白激酶A与L型钙通道及Rad GTP酶相互作用的晶体学、动力学和量热学研究

J Biol Chem. 2025 Jan;301(1):108039. doi: 10.1016/j.jbc.2024.108039. Epub 2024 Nov 29.

Structural determinants of protein kinase A essential for CFTR channel activation.蛋白激酶 A 激活 CFTR 通道的结构决定因素。

Proc Natl Acad Sci U S A. 2024 Nov 12;121(46):e2407728121. doi: 10.1073/pnas.2407728121. Epub 2024 Nov 4.

The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A.αC-β4 环控制蛋白激酶 A 催化亚基中核苷酸和底物之间的变构协同作用。

Elife. 2024 Jun 24;12:RP91506. doi: 10.7554/eLife.91506.

Decoding CPK/SnRK Superfamily Kinase Client Signaling Networks Using Peptide Library and Mass Spectrometry.利用肽库和质谱法解码肌酸磷酸激酶/蔗糖非发酵相关蛋白激酶超家族激酶的客户信号网络

Plants (Basel). 2024 May 27;13(11):1481. doi: 10.3390/plants13111481.

Phosphorylation of the compartmentalized PKA substrate TAF15 regulates RNA-protein interactions.磷酸化区室化的 PKA 底物 TAF15 调节 RNA-蛋白相互作用。

Cell Mol Life Sci. 2024 Apr 3;81(1):162. doi: 10.1007/s00018-024-05204-4.

Systems level analysis of time and stimuli specific signaling through PKA.通过 PKA 进行时间和刺激特异性信号的系统水平分析。

Mol Biol Cell. 2024 Apr 1;35(4):ar60. doi: 10.1091/mbc.E23-02-0066. Epub 2024 Mar 6.

A versatile kinase mobility shift assay (KiMSA) for PKA analysis and cyclic AMP detection in sperm physiology (and beyond).一种用于精子生理学（及其他领域）中蛋白激酶A分析和环磷酸腺苷检测的多功能激酶迁移率变动分析（KiMSA）。

Front Cell Dev Biol. 2024 Feb 20;12:1356566. doi: 10.3389/fcell.2024.1356566. eCollection 2024.

Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A.埃德蒙·菲舍尔的激酶遗产：蛋白激酶抑制剂和蛋白激酶 A 的历史。

IUBMB Life. 2023 Apr;75(4):311-323. doi: 10.1002/iub.2714. Epub 2023 Feb 28.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验