苯代谢产物对体外培养的小鼠造血集落形成细胞的作用。
Action of benzene metabolites on murine hematopoietic colony-forming cells in vitro.
作者信息
Seidel H J, Barthel E, Schäfer F, Schad H, Weber L
机构信息
Institute for Occupational and Social Medicine, University of Ulm, Germany.
出版信息
Toxicol Appl Pharmacol. 1991 Oct;111(1):128-31. doi: 10.1016/0041-008x(91)90141-z.
Five benzene metabolites--phenol, catechol, hydroquinone, parabenzoquinone, and trans,trans-muconaldehyde--were tested in vitro in murine hematopoietic cell cultures for erythrocytic (BFU-E and CFU-E) and granulocytic (CFU-C) colony growth. The dose range was 4 x 10(-4) to 4 x 10(-8) M. Of these compounds, phenol showed the lowest toxicity. In general, CFU-E cultures were far more sensitive than CFU-C and BFU-E. The results are discussed in relation to the test system used, the in vivo sensitivity of CFU-E, and the lack of knowledge about in vivo concentrations of these compounds.
在小鼠造血细胞培养物中对五种苯代谢物——苯酚、邻苯二酚、对苯二酚、对苯醌和反式，反式-粘康醛进行了体外测试，以观察其对红细胞（BFU-E和CFU-E）和粒细胞（CFU-C）集落生长的影响。剂量范围为4×10⁻⁴至4×10⁻⁸M。在这些化合物中，苯酚的毒性最低。一般来说，CFU-E培养物比CFU-C和BFU-E更敏感。结合所使用的测试系统、CFU-E的体内敏感性以及对这些化合物体内浓度缺乏了解的情况对结果进行了讨论。
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