Golding Jean, Steer Colin
Centre for Child and Adolescent Health, Department of Community Based Medicine, University of Bristol, Bristol, UK.
Paediatr Perinat Epidemiol. 2009 Jul;23 Suppl 1:31-8. doi: 10.1111/j.1365-3016.2008.00997.x.
One of the first decisions that needs to be taken when planning a birth cohort concerns the size of the study. This in turn will depend on the research questions to be answered and thence whether environmental exposures and outcomes are measured on a continuum or as dichotomous variables. Here we describe ways in which different birth cohorts have addressed this issue and explore the advantages of smaller detailed studies over larger less-detailed studies.
在规划出生队列研究时，首先要做出的决策之一涉及研究规模。这反过来又取决于要回答的研究问题，进而取决于环境暴露和结局是按连续变量还是二分变量来衡量。在此，我们描述了不同出生队列处理这一问题的方式，并探讨了规模较小但更详细的研究相对于规模较大但不太详细的研究的优势。
