Noyes N, Porcu E, Borini A
Department of Obstetrics and Gynecology, NYU Fertility Center, NYU School of Medicine, New York 10016, USA.
Reprod Biomed Online. 2009 Jun;18(6):769-76. doi: 10.1016/s1472-6483(10)60025-9.
Over the past decade, the number of reported live births resulting from oocyte cryopreservation has rapidly increased. To appreciate the true number of children born, verified live births were tabulated and assessed. A literature search was performed; authors were then contacted to verify birth outcomes and provide updates. A database including all verified live born infants was constructed. A total of 58 reports (1986-2008) were reviewed, which included 609 live born babies (308 from slow freezing, 289 from vitrification and 12 from both methods). Additionally, 327 other live births were verified. Of the total 936 live borns, 1.3% (12) were noted to have birth anomalies: three ventricular septal defects, one choanal and one biliary atresia, one Rubinstein-Taybi syndrome, one Arnold-Chiari syndrome, one cleft palate, three clubfoot and one skin haemangioma. Compared with congenital anomalies occurring in naturally conceived infants, no difference was noted. With more live born data accumulating, this procedure may become mainstream as a fertility preservation option, particularly for women diagnosed with malignancy requiring cytotoxic therapy. A registry would help to assure the safest, most expeditious development of this technology.
在过去十年中，经报告的因卵母细胞冷冻保存而实现的活产数量迅速增加。为了了解实际出生的儿童数量，对已核实的活产进行了列表统计和评估。进行了文献检索；随后与作者联系以核实出生结果并获取最新信息。构建了一个包含所有已核实活产婴儿的数据库。共审查了58份报告（1986 - 2008年），其中包括609名活产婴儿（308名来自慢速冷冻，289名来自玻璃化冷冻，12名来自两种方法）。此外，还核实了327例其他活产情况。在总计936例活产中，有1.3%（12例）被发现有出生缺陷：3例室间隔缺损、1例后鼻孔闭锁和1例胆道闭锁、1例鲁宾斯坦 - 泰比综合征、1例阿诺德 - 基亚里综合征、1例腭裂、3例马蹄内翻足和1例皮肤血管瘤。与自然受孕婴儿中出现的先天性异常相比，未发现差异。随着更多活产数据的积累，该程序可能会成为一种主流的生育力保存选择，特别是对于被诊断患有需要细胞毒性治疗的恶性肿瘤的女性。一个登记系统将有助于确保这项技术以最安全、最迅速的方式发展。
