无所适从：切除双链断裂。

At loose ends: resecting a double-strand break.

作者信息

Bernstein Kara A, Rothstein Rodney

机构信息

Columbia University Medical Center, Department of Genetics & Development, New York, NY 10032, USA.

出版信息

Cell. 2009 May 29;137(5):807-10. doi: 10.1016/j.cell.2009.05.007.

DOI:10.1016/j.cell.2009.05.007

PMID:19490890

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3977653/

Abstract

Double-strand break (DSB) repair is critical for maintaining genomic integrity and requires the processing of the 5' DSB ends. Recent studies have shed light on the mechanism and regulation of DNA end processing during DSB repair by homologous recombination.

摘要

双链断裂（DSB）修复对于维持基因组完整性至关重要，并且需要对5' DSB末端进行加工。最近的研究揭示了同源重组过程中DNA末端加工的机制和调控。