Woods Stephen C
Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA.
Cell Metab. 2009 Jun;9(6):489-98. doi: 10.1016/j.cmet.2009.04.007.
To meet the continuous demand for energy, organisms use diverse signals to match food intake with energy needs. This paper reviews the effect of satiation signals and adiposity signals on food intake, including how they interact in the brain and how their influence changes with experience. Whereas meal initiation is influenced by external environmental factors, meal size is influenced by an array of signals that can be partitioned according to their reliability in indicating caloric content of food. It is argued that the malleability of satiation signals renders them poor candidates as pharmacological targets to control body weight.
为了满足对能量的持续需求，生物体利用多种信号来使食物摄入量与能量需求相匹配。本文综述了饱腹感信号和肥胖信号对食物摄入的影响，包括它们在大脑中的相互作用方式以及它们的影响如何随经验而变化。虽然进食的开始受外部环境因素影响，但进食量受一系列信号影响，这些信号可根据其指示食物热量含量的可靠性进行分类。有人认为，饱腹感信号的可塑性使其不太适合作为控制体重的药理学靶点。
