Département de Microbiologie, Centre Hospitalier Intercommunal de Créteil, Service de Microbiologie, 40 avenue de Verdun, 94 000 Créteil, France.
Vaccine. 2010 Aug 23;28(37):6114-21. doi: 10.1016/j.vaccine.2009.05.037. Epub 2009 May 31.
To determine whether the use of seven valent pneumococcal conjugate vaccine (PCV7) caused a shift in the Streptococcus pneumoniae serotypes distribution and whether it modified the resistance to antibiotics, 3291 nasopharyngeal swabs were obtained between 2001 and 2006, from children aged 6-24 months with acute otitis media. Following the implementation of PCV7, we observed a slight reduction in the overall pneumococcal carriage, a marked decrease of vaccine serotypes, an increase in non-vaccine serotypes carriage and a reduction in the carriage of penicillin non-susceptible strains. Most of the serotype 19A replacement was related to the clonal expansion of ST276 which was found to be the predominant ST among penicillin non-susceptible isolates.
为了确定 7 价肺炎球菌结合疫苗（PCV7）的使用是否导致肺炎链球菌血清型分布发生变化，以及是否改变了对抗生素的耐药性，我们在 2001 年至 2006 年间，从 6-24 个月龄患有急性中耳炎的儿童中获得了 3291 份鼻咽拭子。在实施 PCV7 后，我们观察到总体肺炎球菌携带率略有下降，疫苗血清型显著减少，非疫苗血清型携带率增加，以及青霉素不敏感菌株携带率降低。19A 型血清型的大部分替代与 ST276 的克隆扩张有关，ST276 是青霉素不敏感分离株中主要的 ST 型。
