Epivatianos A, Tsougas M
Stomatologia (Athenai). 1991 Sep-Dec;47(5-6):306-13.
Although hypercalcaemia is considered to be aetiological factor of nephrocalcinosis and uroliths formation, its effect on the major salivary glands, where lithiasis is frequent, has not been studied enough. The purpose of this project was the parallel histologic study of the effect of experimentally induced hypercalcaemia on the kidney and the major salivary glands of the rat. Temporary hypercalcaemia was induced in 17 females rates after 8 daily intraperitoneal doses 1.5 ml of 10% calcium gluconate. After the fixation of the tissues in 4% formaldehyde containing 1% CaCl2, serial sections were stained with haematoxylin and eosin and Von Kossa's method for calcified deposits. In the kidneys calcified deposits were observed in the cytoplasm of the cells of the proximal convoluted tubules, in the basement membrane, and their lumen. The major salivary glands were normal. Calcified deposits were not observed in the glandular parenchyma either in the lumina. The results suggest that during hypercalcaemia the transcellular transport of the calcium continue to be under the normal influence of the autonomic nervous system, preventing the formation of calcified deposits.
尽管高钙血症被认为是肾钙质沉着症和尿路结石形成的病因，但它对结石症频发的主要唾液腺的影响尚未得到充分研究。本项目的目的是对实验性诱导的高钙血症对大鼠肾脏和主要唾液腺的影响进行平行组织学研究。在17只雌性大鼠腹腔内连续8天每天注射1.5毫升10%葡萄糖酸钙后，诱导出暂时性高钙血症。在含有1%氯化钙的4%甲醛中固定组织后，连续切片用苏木精和伊红以及用于钙化沉积物的冯·科萨方法染色。在肾脏中，在近端曲管细胞的细胞质、基底膜及其管腔中观察到钙化沉积物。主要唾液腺正常。在腺实质或管腔中均未观察到钙化沉积物。结果表明，在高钙血症期间，钙的跨细胞转运继续受到自主神经系统的正常影响，从而防止钙化沉积物的形成。
