Gersak Ksenija, Cvijic Marta, Cerar Lilijana Kornhauser
Department of Obstetrics and Gynaecology, University Medical Centre Ljubljana, Slajmerjeva 3, SI-1000 Ljubljana, Slovenia.
Reprod Toxicol. 2009 Jul;28(1):109-12. doi: 10.1016/j.reprotox.2009.02.004. Epub 2009 Feb 24.
To present cases exhibiting possible effects of angiotensin II receptor blockers (ARBs) received in pregnancy on the fetus.
Retrospective analysis included women who delivered between 2002 and 2006 at Department of Obstetrics and Gynaecology Ljubljana.
Antihypertensive medications were prescribed to 346 of the 26,735 women. ARBs were given in only five pregnancies: two women received losartan, and three irbesartan. The therapy was stopped between 5 and 23 weeks of gestation. Two women delivered healthy babies at term; another term baby had one additional finger and toe. Other two pregnancies were complicated with oligohydramnios and ended in preterm delivery. One preterm infant had transient abnormal renal function tests.
Women should be informed that ARB-antihypertensive therapy must be replaced/stopped before planning their pregnancy or at least as soon as the pregnancy is confirmed. Fetal morphology scan and monitoring of amniotic fluid volume should be obligatory, if ARBs are prescribed accidentally.
呈现孕期使用血管紧张素 II 受体阻滞剂（ARB）对胎儿可能产生影响的病例。
回顾性分析纳入了 2002 年至 2006 年在卢布尔雅那妇产科分娩的女性。
在 26735 名女性中，有 346 名女性接受了降压药物治疗。仅 5 例妊娠使用了 ARB：2 名女性使用氯沙坦，3 名使用厄贝沙坦。治疗在妊娠 5 至 23 周期间停止。2 名女性足月分娩出健康婴儿；另一名足月婴儿多了一根手指和一个脚趾。另外 2 例妊娠合并羊水过少并早产。一名早产婴儿肾功能检查有短暂异常。
应告知女性，在计划怀孕前或至少在确认怀孕后应立即停用/更换 ARB 降压治疗。如果意外开具了 ARB，必须进行胎儿形态扫描并监测羊水量。
