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接受单药和双联抗血小板治疗的患者在侵入性牙科治疗后出血并发症的发生率。

The frequency of bleeding complications after invasive dental treatment in patients receiving single and dual antiplatelet therapy.

作者信息

Napeñas Joel J, Hong Catherine H L, Brennan Michael T, Furney Scott L, Fox Philip C, Lockhart Peter B

机构信息

General Practice Residency, Department of Oral Medicine, Carolinas Medical Center, P.O. Box 32861, Charlotte, N.C. 28232, USA.

出版信息

J Am Dent Assoc. 2009 Jun;140(6):690-5. doi: 10.14219/jada.archive.2009.0255.

Abstract

BACKGROUND

The dental literature suggests that a patient's antiplatelet medication schedule should not be altered before invasive dental procedures. The authors conducted a study to examine the frequency of bleeding complications after invasive dental procedures in patients taking antiplatelet medications.

METHODS

In a retrospective study of 43 dental patients who were receiving single or dual antiplatelet therapy, the authors conducted a chart review of patient records and examining documentation of the medical history. They collected demographic data; medical history; medication history; social history; presence of preoperative infection at any dental visit as evidenced by swelling, purulence or periapical radiolucency; number and type of invasive dental visits; emergency department visits; types of dental procedures performed; use of adjunctive perioperative local hemostatic measures (for example, topical thrombin, absorbable gelatin compressed sponge, sutures); blood products used preoperatively and postoperatively; and postoperative complications.

RESULTS

Twenty-nine patients (67 percent) were receiving dual antiplatelet therapy. There were 88 invasive-procedure visits consisting of extractions, periodontal surgery, and subgingival scaling and root planing. The authors found no differences between patients receiving single or dual antiplatelet therapy for all variables, most notably the number of invasive-procedure visits, total extractions and adjunctive hemostatic measures. There were no documented episodes of prolonged postoperative bleeding.

CONCLUSIONS

The frequency of oral bleeding complications after invasive dental procedures was low to negligible for patients who were receiving single or dual antiplatelet therapy.

CLINICAL IMPLICATIONS

The risks of altering or discontinuing use of antiplatelet medications far outweigh the low risk of postoperative oral bleeding complications resulting from dental procedures.

摘要

背景

牙科文献表明,在进行侵入性牙科手术前,不应改变患者的抗血小板药物治疗方案。作者开展了一项研究,以检查服用抗血小板药物的患者在进行侵入性牙科手术后出血并发症的发生频率。

方法

在一项对43例接受单药或双联抗血小板治疗的牙科患者的回顾性研究中,作者对患者记录进行了图表审查并检查了病史记录。他们收集了人口统计学数据、病史、用药史、社会史、任何一次牙科就诊时术前感染的情况(表现为肿胀、化脓或根尖周透射区)、侵入性牙科就诊的次数和类型、急诊就诊情况、所进行的牙科手术类型、围手术期辅助局部止血措施的使用情况(例如,局部凝血酶、可吸收明胶海绵、缝线)、术前和术后使用的血液制品以及术后并发症。

结果

29例患者(67%)接受双联抗血小板治疗。共有88次侵入性手术,包括拔牙、牙周手术以及龈下刮治和根面平整。作者发现,在所有变量方面,接受单药或双联抗血小板治疗的患者之间没有差异,最显著的是侵入性手术次数、拔牙总数和辅助止血措施。没有记录到术后出血时间延长的情况。

结论

对于接受单药或双联抗血小板治疗的患者,侵入性牙科手术后口腔出血并发症的发生频率较低或可忽略不计。

临床意义

改变或停用抗血小板药物的风险远大于牙科手术导致的术后口腔出血并发症的低风险。

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