Spiegel A M, Backlund P S, Butrynski J E, Jones T L, Simonds W F
Molecular Pathophysiology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
Trends Biochem Sci. 1991 Sep;16(9):338-41. doi: 10.1016/0968-0004(91)90139-m.
Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.
