de Mulder Maarten, Oemrawsingh Rohit M, Stam Frank, Boersma Eric, Umans Victor A W M
Department of Cardiology, Medical Centre Alkmaar, Alkmaar, The Netherlands.
Crit Pathw Cardiol. 2009 Jun;8(2):66-70; quiz 71. doi: 10.1097/HPC.0b013e3181a27fcf.
Hyperglycemia is common among patients admitted with acute coronary syndromes (ACS) and is associated with less favorable clinical outcomes. Guidelines for the treatment of hyperglycemia in myocardial infarction are confusing, partly because of lack of sufficient evidence. Neither do we know what the everyday practice on hyperglycemia in ACS is. Therefore the aim of our study is to describe current glucose management in ACS patients in The Netherlands. We designed a multiple-choice questionnaire that was emailed to all 94 independent cardiology departments of each of the 114 hospitals within The Netherlands. We interviewed cardiologists about their specific hospital setting, the presence, content, and actual use of a dedicated hyperglycemia protocol in the setting of ACS. Ninety-four questionnaires were returned (response rate 100%). Only 32% of the respondents reported to have a routinely applied, dedicated hyperglycemia protocol in the setting of ACS. An admission glucose of 13.0 mmol/L is considered a stress value by 60% of respondents. Treatment of hyperglycemia is postponed until after the acute phase (ie, after >6 hours) in 41% of the cardiology departments and in 76% HbA1c is not routinely measured before discharge. Only a minority of Dutch cardiology departments have a routinely applied, dedicated hyperglycemia protocol for patients admitted with ACS. Different views exist on the interpretation of admission hyperglycemia in patients without previously diagnosed diabetes. Dedicated protocols with well-established treatment goals allow early treatment and are mandatory to improve timely metabolic regulation.
高血糖在急性冠状动脉综合征(ACS)患者中很常见,且与较差的临床结局相关。心肌梗死患者高血糖治疗指南令人困惑,部分原因是缺乏足够的证据。我们也不清楚ACS患者高血糖的日常治疗情况。因此,我们研究的目的是描述荷兰ACS患者目前的血糖管理情况。我们设计了一份多项选择题问卷,并通过电子邮件发送给荷兰114家医院中94个独立的心脏病科。我们就其所在医院的具体情况、ACS情况下专门的高血糖治疗方案的存在情况、内容及实际使用情况对心脏病专家进行了访谈。共收回94份问卷(回复率100%)。只有32%的受访者报告在ACS情况下有常规应用的专门高血糖治疗方案。60%的受访者认为入院血糖13.0 mmol/L为应激值。41%的心脏病科将高血糖治疗推迟到急性期之后(即>6小时后),76%的科室在出院前不常规检测糖化血红蛋白(HbA1c)。只有少数荷兰心脏病科对ACS入院患者有常规应用的专门高血糖治疗方案。对于既往未诊断糖尿病患者入院高血糖的解读存在不同观点。制定明确治疗目标的专门方案可实现早期治疗,对改善及时的代谢调节至关重要。