唐氏综合征患儿出现的罕见甲状腺症候群：同一患儿同时患有先天性甲状腺功能减退症、格雷夫斯病和半侧甲状腺发育不全。
Unusual thyroid constellation in Down syndrome: congenital hypothyroidism, Graves' disease, and hemiagenesis in the same child.
作者信息
Nebesio Todd D, Eugster Erica A
机构信息
Department of Pediatrics, Section of Pediatric Endocrinology/Diabetology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
J Pediatr Endocrinol Metab. 2009 Mar;22(3):263-8. doi: 10.1515/jpem.2009.22.3.263.
We report a girl with Down syndrome who was diagnosed with congenital hypothyroidism in the newborn period due to left thyroid hemiagenesis. Unexpectedly, her hypothyroidism resolved at the age of 3 years. After being off thyroid hormone replacement for 7 years and having normal thyroid function, she developed Graves' disease. Although Graves' disease in association with thyroid hemiagenesis has previously been reported, this represents the youngest patient in whom this scenario has been described. Issues pertaining to thyroid hemiagenesis, autoimmune hyperthyroidism, and thyroid disease in children with Down's syndrome are discussed.
我们报告了一名患有唐氏综合征的女孩，她在新生儿期因左侧甲状腺半侧发育不全被诊断为先天性甲状腺功能减退症。出乎意料的是，她的甲状腺功能减退症在3岁时得到缓解。在停用甲状腺激素替代治疗7年且甲状腺功能正常后，她患上了格雷夫斯病。尽管此前已有关于格雷夫斯病与甲状腺半侧发育不全相关的报道，但这是描述此情况的最年轻患者。本文讨论了与唐氏综合征患儿的甲状腺半侧发育不全、自身免疫性甲状腺功能亢进症及甲状腺疾病相关的问题。
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