Nielsen L M, Nielsen S L, Christensen L Q, Steentoft A, Worm K
Anaestesiologisk afdeling R og smerteklinikken, Bispebjerg Hospital.
Ugeskr Laeger. 1991 Sep 23;153(39):2734-7.
All of the Medicolegal Committee's cases from the period 1981-1985 concerning the influence of drugs on motorized road-users were reviewed. Only cases where a drug was demonstrated in blood and/or urine were included. A total of 442 cases were included in this investigation and 100 different agents, drugs and narcotics were demonstrated. In all of the cases the two drugs most frequently demonstrated were diazepam (46%) and morphine (19%). In the 46 cases where diazepam was demonstrated alone (blood alcohol concentration = 0, a significant correlation could be demonstrated between the sum of the blood concentration of diazepam and demethyldiazepam and the degree of intoxication as estimated by the clinical examination. In 87% of the cases, the road-users were men. Cannabis users had a lower age (21 years) than the road-users who had taken diazepam (28 years) or morphine (26 years) while individuals who had taken methadon had a higher average age (29 years) than those who had taken morphine. The frequencies of accidents in cases with morphine or methadon were lower than in the material as a whole while the frequency of accidents for dextropropoxyphen was higher compared with the other opiods and the material as a whole.
对法医学委员会1981年至1985年期间所有关于药物对机动车道路使用者影响的案例进行了回顾。仅纳入血液和/或尿液中检测出药物的案例。本调查共纳入442个案例,检测出100种不同的药剂、药物和麻醉品。在所有案例中,最常检测出的两种药物是地西泮(46%)和吗啡(19%)。在仅检测出地西泮的46个案例中(血液酒精浓度=0),地西泮和去甲基地西泮的血液浓度总和与临床检查估计的中毒程度之间存在显著相关性。在87%的案例中,道路使用者为男性。大麻使用者的年龄(21岁)低于服用地西泮(28岁)或吗啡(26岁)的道路使用者,而服用美沙酮的个体平均年龄(29岁)高于服用吗啡的个体。服用吗啡或美沙酮的案例中的事故发生率低于整个样本,而右丙氧芬的事故发生率高于其他阿片类药物及整个样本。