分娩后胎盘、胎膜和脐带中的芳基硫酸酯酶 A 活性和硫酸脂浓度。

Arylsulphatase A activity and sulphatide concentration in placenta, membranes and cord after delivery.

机构信息

Department of Surgical Sciences, Institute of Obstetrics and Gynecology, University of Foggia, Foggia, Italy.

出版信息

J Perinat Med. 2009;37(5):497-502. doi: 10.1515/JPM.2009.092.

DOI:10.1515/JPM.2009.092

PMID:19492918

Abstract

AIM

We evaluated variations in behavior of arylsulphatase A activity (an enzyme that catabolizes sulphatides) and of sulphatide concentration in the placenta, cord and membranes of healthy gravidas at term pregnancy, following spontaneous birth.

METHODS

We extracted and biochemically determined arylsulphatase A and sulphatide concentration in placenta, cord and membranes (far from and close to internal uterine os) in 14 patients.

RESULTS

Activity of arylsulphatase A decreased in the cord, in membranes far from the internal uterine os, in membranes close to the internal uterine os and in the placenta. Sulphatide concentration was minimal in the cord and maximal in placenta, with intermediate values in the membranes. No correlation was found between arylsulphatase A activity and sulphatide concentration, nor among arylsulphatase A activities, nor among sulphatide concentrations among the different tissues. It seems that multiparity may increase and the duration of active labor may decrease arylsulphatase A activity in membranes far from the internal uterine os, while active labor duration does not appear to have any implication on sulphatide concentration in membranes close to the internal uterine os.

CONCLUSIONS

Arylsulphatase A activities and sulphatide concentrations in fetal adnexa show significant differences.

摘要

目的

我们评估了足月自然分娩后健康孕妇胎盘、脐带和胎膜中芳基硫酸酯酶 A 活性（一种分解硫酸酯的酶）和硫酸酯浓度的变化。

方法

我们从 14 名患者中提取并生化测定了胎盘、脐带和胎膜（远离和靠近子宫内口）中的芳基硫酸酯酶 A 和硫酸酯浓度。

结果

芳基硫酸酯酶 A 活性在脐带、远离子宫内口的胎膜、靠近子宫内口的胎膜和胎盘中降低。硫酸酯浓度在脐带中最低，在胎盘最高，在胎膜中处于中间值。芳基硫酸酯酶 A 活性与硫酸酯浓度之间、不同组织之间的芳基硫酸酯酶 A 活性之间以及硫酸酯浓度之间均无相关性。多胎妊娠似乎会增加远离子宫内口的胎膜中芳基硫酸酯酶 A 活性，而活跃的分娩时间似乎对靠近子宫内口的胎膜中硫酸酯浓度没有任何影响。