脉冲超声与高压暴露的小鼠胎儿

Pulsed ultrasound and the hyperbarically exposed mouse fetus.

作者信息

Child S Z, Hoffman D, Norton S, Carstensen E L, Cox C, Gates A H

机构信息

Department of Electrical Engineering, University of Rochester, NY 14627.

出版信息

Ultrasound Med Biol. 1991;17(4):367-71. doi: 10.1016/0301-5629(91)90136-k.

DOI:10.1016/0301-5629(91)90136-k

PMID:1949348

Abstract

To enhance the likelihood of cavitation, pregnant mice were subjected to hyperbaric conditions and quickly returned to atmospheric pressure. Following this treatment, they were exposed to spatial average, pulse average intensities of 100 W/cm2 (2.2-MHz, 20-microseconds pulses with a duty cycle of 1/1000 or a temporal average spatial average intensity of 0.1 W/cm2). Fetal weights, deaths and malformations were scored. No statistically significant effects were observed in the offspring.

摘要

为提高空化的可能性，对怀孕小鼠施加高压条件，然后迅速恢复到常压。经过这种处理后，使它们暴露于空间平均、脉冲平均强度为100 W/cm²（2.2兆赫、20微秒脉冲、占空比为1/1000）或时间平均空间平均强度为0.1 W/cm²的环境中。对胎儿体重、死亡和畸形情况进行评分。在后代中未观察到统计学上的显著影响。