Lee T P, Reed C E
J Allergy Clin Immunol. 1977 Aug;60(2):141-3. doi: 10.1016/0091-6749(77)90040-9.
Concentrations of 10(-6) to 10(-3) M ephedrine did not increase cyclic adenosine monophosphate (cAMP) levels of normal human lymphocytes even in the presence of theophylline or cortisol, which enhance the response to isoproterenol or prostaglandin E1. Preincubation for 2 hr with ephedrine did not reduce the subsequent effect of isoproterenol, although preincubation with isoproterenol itself did. Therefore, ephedrine is not a direct beta-adrenergic agonist on human peripheral blood lymphocytes.
即使存在茶碱或皮质醇（它们可增强对异丙肾上腺素或前列腺素E1的反应），浓度为10⁻⁶至10⁻³M的麻黄碱也不会增加正常人淋巴细胞中环磷酸腺苷（cAMP）的水平。麻黄碱预孵育2小时不会降低随后异丙肾上腺素的作用，而异丙肾上腺素本身预孵育则会降低其随后的作用。因此，麻黄碱并非人外周血淋巴细胞上的直接β-肾上腺素能激动剂。
