Mackenzie T B, Popkin M K, Dziubinski J, Sheppard J R
Clin Pharmacol Ther. 1981 Oct;30(4):436-8. doi: 10.1038/clpt.1981.185.
The effect of short-term caffeine withdrawal on lymphocyte beta-adrenoceptor sensitivity was studied in seven men who had been drinking coffee daily for at least 3 mo before the study. The ratio of cyclic adenosine monophosphate production after in vitro incubation with isoproterenol and a blank was used to assess receptor sensitivity. There was a reduction in sensitivity to isoproterenol but not to prostaglandin E1 3 days after caffeine withdrawal. The mechanism of this effect is not clear, but may represent a biochemical correlate of caffeine-withdrawal syndrome.
研究了短期咖啡因戒断对淋巴细胞β-肾上腺素能受体敏感性的影响，研究对象为7名男性，他们在研究前至少3个月每天喝咖啡。用异丙肾上腺素和空白对照进行体外孵育后环磷酸腺苷生成的比率来评估受体敏感性。咖啡因戒断3天后，对异丙肾上腺素的敏感性降低，但对前列腺素E1的敏感性未降低。这种效应的机制尚不清楚，但可能代表咖啡因戒断综合征的一种生化关联。
