Institute for Medical Research and Occupational Health, Ksaverska c 2, Zagreb, Croatia.
Med Hypotheses. 2009 Nov;73(5):703-5. doi: 10.1016/j.mehy.2009.03.051. Epub 2009 Jun 2.
The etiology of epilepsy still represents an open subject of discussions and research. Contrary to the majority of diseases for which drugs are developed following the origin of disease, epilepsy is treated symptomatically because it is perceived to have diverse causes. Recent results of oncological, neurological, developmental and biochemical studies suggest that the reproductive dysfunction in men and women, as a side effect related with antiepileptic therapy, points to the single origin of this disease. It seems that contrary to the present definition of estrogen as a compound affecting seizure susceptibility, based on causal chains: of increased estrogen levels (alcohol intake) and seizure, fact that all antiepileptic drugs are aromatase inhibitors or have estrogen binding properties, described cases of seizures in epileptic patients taking quinine as preventive therapy against malaria, impact of photic activation and sleep on estrogen level, it can be assumed that estrogen plays the leading role in the mutual origin of different types of epilepsy.
癫痫的病因仍然是一个讨论和研究的课题。与大多数疾病不同，针对这些疾病，药物是在疾病起源后开发的，而癫痫是对症治疗的，因为它被认为有多种原因。最近的肿瘤学、神经学、发育和生化研究结果表明，男性和女性的生殖功能障碍作为与抗癫痫治疗相关的副作用，指向这种疾病的单一起源。与目前基于因果关系链的定义相反，即雌激素水平升高（饮酒）与癫痫发作之间的关系：所有抗癫痫药物都是芳香酶抑制剂或具有雌激素结合特性，描述了癫痫患者服用奎宁作为预防疟疾的预防性治疗时发生癫痫的病例，光激活和睡眠对雌激素水平的影响，可以假设雌激素在不同类型癫痫的相互起源中起主导作用。
