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加拿大安大略省的结核分枝杆菌：IS6110 限制性片段长度多态性和分枝杆菌插入重复单元可变数目串联重复序列基因分型的见解

Mycobacterium tuberculosis in Ontario, Canada: Insights from IS6110 restriction fragment length polymorphism and mycobacterial interspersed repetitive-unit-variable-number tandem-repeat genotyping.

作者信息

Alexander David C, Guthrie Jennifer L, Pyskir Daria, Maki Anne, Kurepina Natalia, Kreiswirth Barry N, Chedore Pamela, Drews Steven J, Jamieson Frances

机构信息

Ontario Agency for Health Protection and Promotion, Public Health Laboratory-Toronto, Canada.

出版信息

J Clin Microbiol. 2009 Aug;47(8):2651-4. doi: 10.1128/JCM.01946-08. Epub 2009 Jun 3.

DOI:10.1128/JCM.01946-08
PMID:19494075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2725669/
Abstract

A collection of 1,308 clinical Mycobacterium tuberculosis isolates from Ontario, Canada, was genotyped by IS6110 restriction fragment length polymorphism (RFLP) and mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) analysis. RFLP or >12 MIRU-VNTR loci were necessary for resolution of Indo-Oceanic strains. The low clustering rate and high strain diversity indicate that, in Ontario, most tuberculosis results from reactivation of latent infections.

摘要

对来自加拿大安大略省的1308株临床结核分枝杆菌分离株进行了IS6110限制性片段长度多态性（RFLP）和分枝杆菌散布重复单位可变数目串联重复序列（MIRU-VNTR）分析基因分型。RFLP或超过12个MIRU-VNTR位点对于印度洋菌株的分辨是必要的。低聚类率和高菌株多样性表明，在安大略省，大多数结核病是由潜伏感染的重新激活引起的。

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