健康成年人粪便中的多瘤病毒排出情况。
Polyomavirus shedding in the stool of healthy adults.
作者信息
Vanchiere John A, Abudayyeh Suhaib, Copeland Christina M, Lu Lee B, Graham David Y, Butel Janet S
机构信息
Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
出版信息
J Clin Microbiol. 2009 Aug;47(8):2388-91. doi: 10.1128/JCM.02472-08. Epub 2009 Jun 3.
Abstract
We recently reported the frequent detection of polyomaviruses (BK virus [BKV] or simian virus 40 [SV40]) in 46% of stool samples from hospitalized children. In order to determine if adults exhibit fecal shedding of polyomavirus, single stool specimens from healthy adults were evaluated by PCR. Overall, 20 (18.2%) of 110 specimens were positive for human polyomaviruses: 9 with BKV, 9 with JC virus (JCV), 1 with SV40, and 1 with both JCV and SV40. Among the 94 subjects without immune compromise, 17 (18.1%) were excreting polyomaviruses. This shedding frequency in adults was significantly lower than that observed in children (P < 0.001). These findings support the hypothesis that the gastrointestinal tract may be a site of polyomavirus persistence, and they suggest a fecal-oral route of viral transmission.
摘要
我们最近报告称，在住院儿童46%的粪便样本中频繁检测到多瘤病毒（BK病毒[BKV]或猴病毒40[SV40]）。为了确定成人是否存在多瘤病毒的粪便排泄情况，我们通过聚合酶链反应（PCR）对健康成人的单个粪便标本进行了评估。总体而言，110份标本中有20份（18.2%）人多瘤病毒呈阳性：9份为BKV阳性，9份为JC病毒（JCV）阳性，1份为SV40阳性，1份JCV和SV40均为阳性。在94名无免疫功能低下的受试者中，17名（18.1%）正在排泄多瘤病毒。成人的这种排泄频率显著低于儿童（P<0.001）。这些发现支持了胃肠道可能是多瘤病毒持续存在部位的假说，并提示了病毒的粪-口传播途径。
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