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Int J Cancer. 2009 Feb 1;124(3):516-20. doi: 10.1002/ijc.24010.
2
Detection and differentiation of human papillomavirus genotypes HPV-6 and HPV-11 by FRET-based real-time PCR.基于荧光共振能量转移的实时聚合酶链反应检测和鉴别人乳头瘤病毒6型和11型基因型
J Virol Methods. 2008 Nov;153(2):245-9. doi: 10.1016/j.jviromet.2008.07.014. Epub 2008 Sep 4.
3
Human papillomavirus genotype distribution in external acuminata condylomata: a Large French National Study (EDiTH IV).尖锐湿 疣患者的人乳头瘤病毒基因型分布：一项大型法国全国性研究（EDiTH IV）
Clin Infect Dis. 2008 Sep 1;47(5):610-5. doi: 10.1086/590560.
4
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J Clin Microbiol. 2008 Aug;46(8):2595-604. doi: 10.1128/JCM.00824-08. Epub 2008 Jun 25.
5
Distribution of human papillomavirus (HPV) genotypes in genital warts from males in Slovenia.斯洛文尼亚男性尖锐湿疣患者人乳头瘤病毒（HPV）基因型分布情况
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杂交捕获2型低风险探针组合的人乳头瘤病毒基因型特异性

Human papillomavirus genotype specificity of hybrid capture 2 low-risk probe cocktail.

作者信息

Poljak Mario, Kocjan Bostjan J, Kovanda Anja, Lunar Maja M, Lepej Snjezana Zidovec, Planinic Ana, Seme Katja, Vince Adriana

机构信息

Institute of Microbiology and Immunology, University of Ljubljana, Slovenia.

出版信息

J Clin Microbiol. 2009 Aug;47(8):2611-5. doi: 10.1128/JCM.00278-09. Epub 2009 Jun 3.

DOI:10.1128/JCM.00278-09
PMID:19494080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2725686/
Abstract

A genotyping study of 285 Hybrid Capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. Cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. A total of 8.4% of positive results, usually weak, were due to cross-reactivity with high-risk genotypes. Establishment of a gray zone is recommended.

摘要

一项对285份杂交捕获2低风险探针混合检测呈阳性样本的基因分型研究显示，其与几种非靶向人乳头瘤病毒基因型存在交叉反应性。由于检测到非靶向低风险基因型，交叉反应性通常在临床上有益。共有8.4%的阳性结果（通常较弱）是由于与高风险基因型的交叉反应性所致。建议建立一个灰区。