Sohrabi Hamid R, Bates Kristyn A, Rodrigues Mark, Taddei Kevin, Martins Georgia, Laws Simon M, Lautenschlager Nicola T, Dhaliwal Satvinder S, Foster Jonathan K, Martins Ralph N
The School of Psychiatry and Clinical Neuroscience, University of Western Australia, WA, Australia.
J Alzheimers Dis. 2009;17(1):69-79. doi: 10.3233/JAD-2009-1018.
Apolipoprotein E epsilon4 (APOE-epsilon4) is a major genetic risk factor for Alzheimer's disease. In this study, we addressed the question of whether possession of the APOE-epsilon4 allele results in adverse effects on perceived health-related quality of life (HRQL) and on symptoms of depression and anxiety in people with subjective memory complaints (SMC). 138 healthy, community-dwelling elderly volunteers, aged 52 to 85, were assessed for HRQL, depression, and anxiety. The participants were classified as i) APOE-epsilon4 carriers or ii) non-carriers with a) SMC or b) without memory complaints. The possible interactions of APOE genotype, gender, and SMC on HRQL, depression, and anxiety were investigated statistically. SMC was significantly associated with poorer outcomes on measures of depression, trait anxiety, and mental health. APOE-epsilon4 carriers did not significantly differ from non-carriers on HRQL, depression, and anxiety. However, significant interaction was found between APOE-epsilon4 genotype and SMC on depression. These findings are important from a health perspective and suggest that memory complaints are associated with markers of mental health and quality of life that are independent of possession of the APOE-epsilon4 allele, despite the importance of this polymorphism in the risk of AD and other health problems.
载脂蛋白Eε4（APOE-ε4）是阿尔茨海默病的主要遗传风险因素。在本研究中，我们探讨了携带APOE-ε4等位基因是否会对主观记忆障碍（SMC）患者的健康相关生活质量（HRQL）以及抑郁和焦虑症状产生不利影响。对138名年龄在52至85岁之间、居住在社区的健康老年志愿者进行了HRQL、抑郁和焦虑评估。参与者被分为：i）APOE-ε4携带者；ii）非携带者，其中又分为a）有SMC者和b）无记忆障碍者。对APOE基因型、性别和SMC在HRQL、抑郁和焦虑方面的可能相互作用进行了统计学研究。SMC与抑郁、特质焦虑和心理健康测量指标的较差结果显著相关。APOE-ε4携带者在HRQL、抑郁和焦虑方面与非携带者没有显著差异。然而，发现APOE-ε4基因型和SMC在抑郁方面存在显著相互作用。从健康角度来看，这些发现很重要，表明记忆障碍与心理健康和生活质量指标相关，这些指标独立于APOE-ε4等位基因的携带情况，尽管这种多态性在AD风险和其他健康问题中很重要。
