Schüz Joachim, Böhler Eva, Berg Gabriele, Schlehofer Brigitte, Hettinger Iris, Schlaefer Klaus, Wahrendorf Jürgen, Kunna-Grass Katharina, Blettner Maria
Institute of Medical Biostatistics, Epidemiology and Informatics, Johannes Gutenberg-University of Mainz, Mainz, Germany.
Am J Epidemiol. 2006 Mar 15;163(6):512-20. doi: 10.1093/aje/kwj068. Epub 2006 Jan 27.
The widespread use of cellular telephones has generated concern about possible adverse health effects, particularly brain tumors. In this population-based case-control study carried out in three regions of Germany, all incident cases of glioma and meningioma among patients aged 30-69 years were ascertained during 2000-2003. Controls matched on age, gender, and region were randomly drawn from population registries. In total, 366 glioma cases, 381 meningioma cases, and 1,494 controls were interviewed. Overall use of a cellular phone was not associated with brain tumor risk; the respective odds ratios were 0.98 (95% confidence interval (CI): 0.74, 1.29) for glioma and 0.84 (95% CI: 0.62, 1.13) for meningioma. Among persons who had used cellular phones for 10 or more years, increased risk was found for glioma (odds ratio = 2.20, 95% CI: 0.94, 5.11) but not for meningioma (odds ratio = 1.09, 95% CI: 0.35, 3.37). No excess of temporal glioma (p = 0.41) or meningioma (p = 0.43) was observed in cellular phone users as compared with nonusers. Cordless phone use was not related to either glioma risk or meningioma risk. In conclusion, no overall increased risk of glioma or meningioma was observed among these cellular phone users; however, for long-term cellular phone users, results need to be confirmed before firm conclusions can be drawn.
移动电话的广泛使用引发了人们对其可能产生的不良健康影响的担忧，尤其是脑肿瘤。在德国三个地区开展的这项基于人群的病例对照研究中，确定了2000年至2003年期间30至69岁患者中所有新诊断的神经胶质瘤和脑膜瘤病例。从人口登记处随机抽取年龄、性别和地区匹配的对照。总共对366例神经胶质瘤病例、381例脑膜瘤病例和1494名对照进行了访谈。移动电话的总体使用与脑肿瘤风险无关；神经胶质瘤的相应比值比为0.98（95%置信区间（CI）：0.74，1.29），脑膜瘤为0.84（95%CI：0.62，1.13）。在使用移动电话10年或更长时间的人群中，发现神经胶质瘤风险增加（比值比=2.20，95%CI：0.94，5.11），但脑膜瘤未增加（比值比=1.09，95%CI：0.35，3.37）。与未使用移动电话的人相比，未观察到移动电话使用者的颞叶神经胶质瘤（p=0.41）或脑膜瘤（p=0.43）有过量情况。无绳电话的使用与神经胶质瘤风险或脑膜瘤风险均无关。总之，在这些移动电话使用者中未观察到神经胶质瘤或脑膜瘤的总体风险增加；然而，对于长期移动电话使用者，在得出确切结论之前，结果需要得到证实。
