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散发性包涵体肌炎患者进行运动训练计划后有氧能力的改善

Improvement in aerobic capacity after an exercise program in sporadic inclusion body myositis.

作者信息

Johnson Liam G, Collier Kelly E, Edwards Dylan J, Philippe Danielle L, Eastwood Peter R, Walters Susan E, Thickbroom Gary W, Mastaglia Frank L

机构信息

Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Perth, Western Australia.

出版信息

J Clin Neuromuscul Dis. 2009 Jun;10(4):178-84. doi: 10.1097/CND.0b013e3181a23c86.

Abstract

OBJECTIVES

The study aimed to investigate the effects of a combined functional and aerobic exercise program on aerobic capacity, muscle strength, and functional mobility in a group of patients with sporadic inclusion body myositis (IBM).

METHODS

Aerobic capacity, muscle strength, and functional capacity assessments were conducted on 7 participants with sporadic IBM before and after a 12-week exercise program, which included resistance exercises and aerobic stationary cycling 3 times per week on alternative days.

RESULTS

Aerobic capacity of the group increased significantly by 38%, and significant strength improvements were observed in 4 of the muscle groups tested (P < 0.05). The exercise program was well tolerated, and there was no significant change in the serum creatine kinase level after the exercise period.

CONCLUSIONS

An aerobic exercise program can be safely tolerated by patients with sporadic IBM and can improve aerobic capacity and muscle strength when combined with resistance training. These findings indicate that aerobic and functional muscle strengthening exercise should be considered in the management of patients with IBM.

摘要

目的

本研究旨在调查一项综合功能锻炼和有氧运动计划对一组散发性包涵体肌炎(IBM)患者的有氧运动能力、肌肉力量和功能活动能力的影响。

方法

对7名散发性IBM患者在为期12周的锻炼计划前后进行了有氧运动能力、肌肉力量和功能能力评估,该锻炼计划包括阻力训练和每周3次、隔天进行的有氧固定自行车运动。

结果

该组患者的有氧运动能力显著提高了38%,在测试的4个肌肉群中观察到力量有显著改善(P<0.05)。锻炼计划耐受性良好,锻炼期后血清肌酸激酶水平无显著变化。

结论

散发性IBM患者能够安全耐受有氧运动计划,并且与阻力训练相结合时可提高有氧运动能力和肌肉力量。这些发现表明,在IBM患者的管理中应考虑进行有氧和功能性肌肉强化锻炼。

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