一水肌酸对老年人及临床人群的补充作用。
Creatine monohydrate supplementation for older adults and clinical populations.
作者信息
Candow Darren G, Ostojic Sergej M, Chilibeck Philip D, Longobardi Igor, Gualano Bruno, Tarnopolsky Mark A, Wallimann Theo, Moriarty Terence, Kreider Richard B, Forbes Scott C, Schlattner Uwe, Antonio Jose
机构信息
University of Regina, Faculty of Kinesiology and Health Studies, Regina SK, Canada.
University of Agder, Department of Nutrition and Public Health, Kristiansand, Norway.
出版信息
J Int Soc Sports Nutr. 2025 Sep;22(sup1):2534130. doi: 10.1080/15502783.2025.2534130. Epub 2025 Jul 17.
BACKGROUND
The biological process of aging is typically associated with a decrease in muscle quantity, muscle performance (primarily strength), bone mass and architecture, functionality and neurological/cognitive function. From a healthy aging perspective, interventions that have the potential to overcome or attenuate these decrements are clinically relevant.
METHODS
We conducted a narrative review on the efficacy of creatine monohydrate supplementation (CrM) in older adults.
RESULTS
Accumulating research shows that CrM, primarily when combined with exercise training, is safe and has beneficial effects on measures of whole-body lean body mass, regional muscle size, muscle strength, bone area and thickness, functional ability, glucose kinetics, cognition and memory.
CONCLUSION
CrM has multiple benefits in older adults and may have application for treating age-related sarcopenia, osteoporosis, frailty, and those with metabolic and neuromuscular disorders.
背景
衰老的生物学过程通常与肌肉量减少、肌肉功能（主要是力量）、骨量和骨结构、功能以及神经/认知功能下降有关。从健康老龄化的角度来看，有可能克服或减轻这些衰退的干预措施具有临床意义。
方法
我们对补充一水肌酸（CrM）对老年人的疗效进行了叙述性综述。
结果
越来越多的研究表明，CrM主要与运动训练结合使用时是安全的，并且对全身瘦体重、局部肌肉大小、肌肉力量、骨面积和厚度、功能能力、葡萄糖动力学、认知和记忆等指标有有益影响。
结论
CrM对老年人有多种益处，可能适用于治疗与年龄相关的肌肉减少症、骨质疏松症、虚弱症以及患有代谢和神经肌肉疾病的患者。
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