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钝性创伤性主动脉损伤:血管内修复的初步经验。

Blunt traumatic aortic injury: initial experience with endovascular repair.

作者信息

Azizzadeh Ali, Keyhani Kourosh, Miller Charles C, Coogan Sheila M, Safi Hazim J, Estrera Anthony L

机构信息

Department of Cardiothoracic and Vascular Surgery, University of Texas Health Science Center, Memorial Hermann Heart and Vascular Institute, Houston, TX, USA.

出版信息

J Vasc Surg. 2009 Jun;49(6):1403-8. doi: 10.1016/j.jvs.2009.02.234.

Abstract

OBJECTIVES

Endovascular treatment of traumatic aortic injury (TAI) is an alternative to open repair (OR) in patients with blunt trauma. We report our initial experience after integration of endovascular repair using thoracic devices.

METHODS

A retrospective review of a prospectively collected institutional trauma registry was performed. Between September 2005 and November 2008, 71 patients with TAI presented to our institution. Based on imaging, TAIs were classified into grade 1-4 in severity. These included: grade 1, intimal tear; grade 2, intramural hematoma; grade 3, aortic pseudoaneurysm; and grade 4, free rupture. Initial management included resuscitation, blood pressure control, and treatment of associated injuries. After stabilization, all patients were considered for thoracic endovascular aortic repair (TEVAR) using a thoracic device. If contraindicated, candidates underwent OR. Outcome measures were mortality, stroke, paraplegia, intensive care unit (ICU), and hospital stay.

RESULTS

The mean age was 39.8 years, with 50 males. The mean injury severity score (ISS) was 42.6. Nineteen (27%) patients with a mean ISS of 60 died shortly after arrival prior to any vascular intervention. Ten (14%) patients with grade 1 injuries were managed medically. The remaining 42 (59%) patients with grade 2 and 3 injuries underwent repair. Median interval between admission and repair was 4.3 days (range, 0-109 days). Fifteen (21%) patients with a mean ISS of 34.4 underwent OR with no mortality, stroke, or paraplegia. Twenty-seven (38%) patients with a mean ISS of 36.7 underwent TEVAR with no mortality or paraplegia. One TEVAR patient suffered a perioperative stroke. Twenty-two patients had a TAG (W.L. Gore & Associates, Flagstaff, Ariz) device. Four patients had a Talent Thoracic (Medtronic Vascular, Santa Rosa, Calif), and 1 patient had an Excluder (W.L. Gore) device. The left subclavian artery was covered in 13 (48%) patients. Patients who underwent TEVAR were older than those who had OR (47.8 vs 31.1 years, P < .006). The aortic diameter proximal to the injury was larger in the TEVAR group (24.4 vs 19.6 mm, P < .0001). There was no difference in the mean ICU or hospital length of stay between the two groups. Mortality correlated with the ISS score (P < .0001). Median follow-up time was 19.4 months (range, 0-27). Only 56% of the TEVAR patients were fully compliant with their surveillance imaging protocol.

CONCLUSION

In this initial experience, the results of TEVAR did not differ from OR. Long-term follow-up is required to determine the effectiveness of this treatment strategy. Adherence to follow-up imaging protocols is challenging in this patient population. Next generation devices will make TEVAR applicable to a wider range of patients.

摘要

目的

对于钝性创伤患者,创伤性主动脉损伤(TAI)的血管内治疗是开放性修复(OR)的一种替代方法。我们报告使用胸段装置进行血管内修复后的初步经验。

方法

对前瞻性收集的机构创伤登记数据进行回顾性分析。2005年9月至2008年11月期间,71例TAI患者就诊于我院。根据影像学检查,TAI的严重程度分为1 - 4级。其中包括:1级,内膜撕裂;2级,壁内血肿;3级,主动脉假性动脉瘤;4级,游离破裂。初始治疗包括复苏、血压控制以及相关损伤的处理。病情稳定后,所有患者均考虑使用胸段装置进行胸段血管内主动脉修复(TEVAR)。若有禁忌证,则行开放性修复。观察指标包括死亡率、卒中、截瘫、重症监护病房(ICU)住院时间和住院总时长。

结果

平均年龄为39.8岁,男性50例。平均损伤严重程度评分(ISS)为42.6。19例(27%)平均ISS为60的患者在到达后未进行任何血管干预前短期内死亡。10例(14%)1级损伤患者接受保守治疗。其余42例(59%)2级和3级损伤患者接受修复治疗。入院至修复的中位间隔时间为4.3天(范围0 - 109天)。15例(21%)平均ISS为34.4的患者接受开放性修复,无死亡、卒中或截瘫发生。27例(38%)平均ISS为36.7的患者接受TEVAR治疗,无死亡或截瘫发生。1例TEVAR患者发生围手术期卒中。22例患者使用TAG(美国亚利桑那州弗拉格斯塔夫市W.L. Gore & Associates公司)装置。4例患者使用Talent Thoracic(美国加利福尼亚州圣罗莎市美敦力血管公司)装置,1例患者使用Excluder(W.L. Gore)装置。13例(48%)患者的左锁骨下动脉被覆盖。接受TEVAR治疗的患者比接受开放性修复的患者年龄更大(47.8岁对31.1岁,P < 0.006)。TEVAR组损伤近端的主动脉直径更大(24.4 mm对19.6 mm,P < 0.0001)。两组间ICU平均住院时间和住院总时长无差异。死亡率与ISS评分相关(P < 0.0001)。中位随访时间为19.4个月(范围0 - 27个月)。仅56%的TEVAR患者完全遵守其随访影像学检查方案。

结论

在这一初步经验中,TEVAR的结果与开放性修复无异。需要长期随访以确定该治疗策略的有效性。在这一患者群体中,遵守随访影像学检查方案具有挑战性。下一代装置将使TEVAR适用于更广泛的患者群体。

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