转化生长因子β1（TGFB1）在生殖中的重要作用。
The essential roles of TGFB1 in reproduction.
作者信息
Ingman Wendy V, Robertson Sarah A
机构信息
Discipline Obstetrics and Gynaecology and Research Centre for Reproductive Health, University of Adelaide, South Australia 5005, Australia.
出版信息
Cytokine Growth Factor Rev. 2009 Jun;20(3):233-9. doi: 10.1016/j.cytogfr.2009.05.003. Epub 2009 Jun 3.
Transforming growth factor beta 1 (TGFB1) is implicated as a key regulator of the development and cyclic remodelling characteristic of reproductive tissues. The physiological significance of TGFB1 in reproductive biology and fertility has been extensively examined in Tgfb1 null mutant mice. Genetic deficiency in TGFB1 causes perturbed functioning of the hypothalamic-pituitary-gonadal axis, inhibiting luteinising hormone (LH) synthesis and leading to downstream effects on testosterone production in males and estrous cycle abnormalities in females. Oocyte developmental incompetence, accompanied by early embryo arrest as well as altered pubertal mammary gland morphogenesis are observed. In addition to LH and testosterone deficiency, male Tgfb1 null mice demonstrate complete inability to mate with females, associated with failure to initiate and/or sustain successful penile intromission or ejaculation. These studies demonstrate the profound significance of TGFB1 in male and female reproductive physiology, and provide a foundation for exploring the significance of this cytokine in human infertility and sexual dysfunction.
转化生长因子β1（TGFB1）被认为是生殖组织发育和周期性重塑特征的关键调节因子。在Tgfβ1基因敲除突变小鼠中，已广泛研究了TGFB1在生殖生物学和生育能力方面的生理意义。TGFB1基因缺陷会导致下丘脑 - 垂体 - 性腺轴功能紊乱，抑制促黄体生成素（LH）合成，并对雄性的睾酮产生和雌性的发情周期异常产生下游影响。观察到卵母细胞发育无能，伴有早期胚胎停滞以及青春期乳腺形态发生改变。除了LH和睾酮缺乏外，雄性Tgfβ1基因敲除小鼠表现出完全无法与雌性交配，这与无法启动和/或维持成功的阴茎插入或射精有关。这些研究证明了TGFB1在男性和女性生殖生理学中的深远意义，并为探索这种细胞因子在人类不孕症和性功能障碍中的意义提供了基础。
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