Omer Hemn Abdalla, Janson Christer, Amin Kawa
Department of Microbiology/Immunology, College of Medicine, University of Suleimani, Sulaymaniyah, Iraq.
Department of Medical Science, Respiratory Medicine, and Allergology, Uppsala University and University Hospital, Uppsala, Sweden.
Cent Eur J Immunol. 2023;48(4):330-337. doi: 10.5114/ceji.2023.133725. Epub 2023 Dec 13.
Biomarkers play a crucial role in evaluating the prognosis, diagnosis, and monitoring of non-small cell lung cancer (NSCLC). The aim of this study was to compare the levels of inflammatory and remodelling biomarkers among patients with NSCLC and healthy controls (HCs) and to investigate the correlation between these biomarkers.
Blood samples were taken from 93 NSCLC and 84 HCs. Each sample was analysed for the inflammatory biomarkers transforming growth factor β1 (TGF-β1), mothers against decapentaplegic homolog 2 (SMAD2) and the remodelling biomarkers Wingless-related integration site (Wnt3a) and α-catenin (CTNN-β1).
The patients with NSCLC had significantly higher levels of all the measured biomarkers. In the NSCLC patients, TGF-β1 correlated significantly with SMAD2 (r = 0.34, p = 0.0008), Wnt3a (r = 0.328, p = 0.0013), and CTNN-β1 levels (r = 0.30, p = 0.004). SMAD2 correlated significantly with CTNN-β1 (r = 0.546, p = 0.0001) and Wnt3a (r = 0.598, p = 0.0001). CTNN-β1 level also correlated with the level of Wnt3a (r = 0.61, p = 0.0001). No correlation was found between biomarkers and symptom scores.
In this study, patients with NSCLC had higher inflammatory and remodelling biomarker levels than HCs. In the NSCLC, there were significant associations between inflammatory and remodelling biomarkers. This indicates that measuring biomarkers could be valuable in the workup of NSCLC patients.
Our investigation showed that inflammatory and remodelling biomarkers might play a role in future immunologic response and pharmacologically targeted NSCLC therapy.
生物标志物在评估非小细胞肺癌（NSCLC）的预后、诊断和监测中起着至关重要的作用。本研究的目的是比较NSCLC患者与健康对照者（HCs）中炎症和重塑生物标志物的水平，并研究这些生物标志物之间的相关性。
采集了93例NSCLC患者和84例HCs的血样。对每个样本分析炎症生物标志物转化生长因子β1（TGF-β1）、抗五肢瘫蛋白同源物2（SMAD2）以及重塑生物标志物无翅相关整合位点（Wnt3a）和α-连环蛋白（CTNN-β1）。
NSCLC患者所有检测的生物标志物水平均显著更高。在NSCLC患者中，TGF-β1与SMAD2（r = 0.34，p = 0.0008）、Wnt3a（r = 0.328，p = 0.0013）和CTNN-β1水平（r = 0.30，p = 0.004）显著相关。SMAD2与CTNN-β1（r = 0.546，p = 0.0001）和Wnt3a（r = 0.598，p = 0.0001）显著相关。CTNN-β1水平也与Wnt3a水平相关（r = 0.61，p = 0.0001）。未发现生物标志物与症状评分之间存在相关性。
在本研究中，NSCLC患者的炎症和重塑生物标志物水平高于HCs。在NSCLC中，炎症和重塑生物标志物之间存在显著关联。这表明检测生物标志物在NSCLC患者的检查中可能具有重要价值。
我们的研究表明，炎症和重塑生物标志物可能在未来的免疫反应和NSCLC药物靶向治疗中发挥作用。
